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Senexin A

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Purity:98%

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COA HNMR

Senexin A

Catalog No. T5673Cas No. 1366002-50-7

Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.

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Pack Size	Price	Availability
1 mg	$51	In Stock
2 mg	$72	In Stock
5 mg	$116	In Stock
10 mg	$168	In Stock
25 mg	$328	In Stock
50 mg	$597	In Stock
100 mg	$852	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock

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Product Introduction

Bioactivity

Description	Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.
Targets&IC50	CDK19:0.31 μm, CDK8:0.83 μM
In vitro	Senexin A inhibited CDK8 and CDK19 ATP site binding with Kd50 of 0.83 μM and 0.31 μM, respectively and CDK8 kinase activity with IC50 of 0.28 μM.CDK8 stimulates Wnt/β-catenin, and Senexin A inhibits β-catenin–dependent transcription in HCT116 colon carcinoma cells.
In vivo	Administering Senexin A daily for five days completely counteracts the tumor-promoting effects of chemotherapy, displaying no detectable toxicity or significant impacts on body weight, organ weights, or blood cell counts in C57BL/6 mice. The adverse effects of doxorubicin treatment are entirely negated when followed by Senexin A administration, significantly enhancing the responsiveness of A549/MEF tumors to doxorubicin.
Animal Research	Tumor-free C57BL/6-derived SCID mice were injected with a single dose of doxorubicin or carrier control.?Five days later, mice received. injection of 2 × 10^6 human A549 lung carcinoma cells, and tumor take was measured over 4 wk.

Chemical Properties

Molecular Weight	274.32
Formula	C17H14N4
Cas No.	1366002-50-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (364.54 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6454 mL	18.2269 mL	36.4538 mL	182.2689 mL
5 mM	0.7291 mL	3.6454 mL	7.2908 mL	36.4538 mL
10 mM	0.3645 mL	1.8227 mL	3.6454 mL	18.2269 mL
20 mM	0.1823 mL	0.9113 mL	1.8227 mL	9.1134 mL
50 mM	0.0729 mL	0.3645 mL	0.7291 mL	3.6454 mL
100 mM	0.0365 mL	0.1823 mL	0.3645 mL	1.8227 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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