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Leucettine L41
🥰Excellent
Catalog No. T24402Cas No. 1112978-84-3
Alias LeucettineL41
Leucettine L41 (LeucettineL41) is a selective DYRK1A inhibitor that inhibits DYRK2, CLK1, and CLK3, inducing autophagy linked to CLK inhibition. It is used to study Alzheimer's disease and memory deficits.
Leucettine L41
🥰Excellent
Purity: 99.08%
Catalog No. T24402Alias LeucettineL41Cas No. 1112978-84-3
Leucettine L41 (LeucettineL41) is a selective DYRK1A inhibitor that inhibits DYRK2, CLK1, and CLK3, inducing autophagy linked to CLK inhibition. It is used to study Alzheimer's disease and memory deficits.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $81 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $373 | In Stock | |
| 25 mg | $616 | In Stock | |
| 50 mg | $872 | In Stock |
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Purity:99.08%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Leucettine L41 (LeucettineL41) is a selective DYRK1A inhibitor that inhibits DYRK2, CLK1, and CLK3, inducing autophagy linked to CLK inhibition. It is used to study Alzheimer's disease and memory deficits. |
| Targets&IC50 | Dyrk2:0.035 µM, Dyrk1A:0.04 µM, CLK1:0.015 µM, CLK3:4.5 µM |
| In vitro | Leucettine L41 is a potent inhibitor of bispecic tyrosine phosphorylated regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 with IC50 of 0.04, 0.035, 0.015, and 4.5 µM, respectively. Leucettine L41 inhibits phosphorylation of serine/arginine-rich protein (SRp). [1] |
| In vivo | Leucettine L41(0.4, 1.2, 4 μg) prevented Aβ25-35-induced hippocampal memory impairment and neurotoxicity in mice. [2] Leucettine L41(20 mg/kg, peritoneal injection) AAV-AD rat model showed decreased soluble P-tau form but unchanged soluble Aβ42 level. [4] |
| Alias | LeucettineL41 |
| Molecular Weight | 307.3 |
| Formula | C17H13N3O3 |
| Cas No. | 1112978-84-3 |
| Smiles | C(\C=1C=C2C(=CC1)OCO2)=C/3\NC(NC4=CC=CC=C4)=NC3=O |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80.00 mg/mL (260.33 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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