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TG003
🥰Excellent
Catalog No. T60367Cas No. 719277-26-6
Alias TG 003
TG003 is a potent Clk1/Sty inhibitor that inhibits Clk1 and Clk4, inhibits cancer cell growth and induces apoptosis, and can be used in the study of Duchenne muscular dystrophy.
TG003
🥰Excellent
Catalog No. T60367Alias TG 003Cas No. 719277-26-6
TG003 is a potent Clk1/Sty inhibitor that inhibits Clk1 and Clk4, inhibits cancer cell growth and induces apoptosis, and can be used in the study of Duchenne muscular dystrophy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $43 | In Stock | |
| 5 mg | $98 | In Stock | |
| 10 mg | $162 | In Stock | |
| 25 mg | $296 | In Stock | |
| 50 mg | $489 | In Stock | |
| 100 mg | $588 | In Stock | |
| 200 mg | $853 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $179 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TG003 is a potent Clk1/Sty inhibitor that inhibits Clk1 and Clk4, inhibits cancer cell growth and induces apoptosis, and can be used in the study of Duchenne muscular dystrophy. |
| Targets&IC50 | CLK4:15–20 nM, CLK2:200 nM, CLK1/Sty:15–20 nM |
| In vitro | The small drug TG003 increases endogenous expression of p53β and p53γ protein isoforms by modulation of TP53 intron 9 alternative splicing. [1] TG003 exhibits the most potent effect on Clk1/Sty and Clk4 (IC50, 15–20 nM) with lesser effect on Clk2 (IC50=200 nM). TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA in vitro by suppression of Clk-mediated phosphorylation. [2] |
| In vivo | Intrathecal injection of either TG003 (1-100 pM) or IC261 (0.1-1 nM) dose-dependently reduces mechanical allodynia and thermal hyperalgesia induced by carrageenan or CFA. [3] |
| Alias | TG 003 |
| Molecular Weight | 249.33 |
| Formula | C13H15NO2S |
| Cas No. | 719277-26-6 |
| Smiles | C(C)N\1C=2C(S/C1=C\C(C)=O)=CC=C(OC)C2 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL(401.07 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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