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(R)-CR8
🥰Excellent
Catalog No. T12617LCas No. 294646-77-8
Alias CR8, (R)-Isomer
(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.
(R)-CR8
🥰Excellent
Purity: 98.41%
Catalog No. T12617LAlias CR8, (R)-IsomerCas No. 294646-77-8
(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $61 | In Stock | |
| 5 mg | $147 | In Stock | |
| 10 mg | $222 | In Stock | |
| 25 mg | $375 | In Stock | |
| 50 mg | $552 | In Stock | |
| 100 mg | $787 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $162 | In Stock |
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Purity:98.41%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | (R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor. |
| Targets&IC50 | CK1δ/ε:0.4 μM, CDK1-CyclinB:0.09 μM, CDK9-CyclinT:0.18 μM, CDK2-CyclinA:0.072 μM, CDK5-p25:0.11 μM, CDK2-CyclinE:0.041 μM, CDK7-CyclinH:1.1 μM |
| In vivo | A delayed systemic post-LFP administration at 3 hours of CR8--a potent second-generation cyclin-dependent kinase (CDK) inhibitor--reduced CCA;?cortical, hippocampal, and thalamic neuronal loss;?and cortical microglial and astrocyte activation.?Furthermore, CR8 treatment attenuated sensorimotor and cognitive deficits, alleviated depressive-like symptoms, and decreased lesion volume[1]. |
| Alias | CR8, (R)-Isomer |
| Molecular Weight | 431.53 |
| Formula | C24H29N7O |
| Cas No. | 294646-77-8 |
| Smiles | CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c2ccccn2)c2ncn(C(C)C)c2n1 |
| Relative Density. | 1.27 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 11 mg/mL (25.49 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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