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Nimbolide

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Purity:99.28%

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COA HNMR HPLC

Nimbolide

Catalog No. T16324Cas No. 25990-37-8

Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-κB. Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica L).

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Pack Size	Price	Availability
1 mg	$128	In Stock
5 mg	$398	In Stock
10 mg	$658	In Stock
25 mg	$1,098	In Stock
50 mg	$2,038	In Stock
100 mg	$2,998	In Stock
500 mg	$8,950	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	466.52
Formula	C27H30O7
Cas No.	25990-37-8

Storage & Solubility Information

Storage

keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (128.61 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1435 mL	10.7177 mL	21.4353 mL	107.1765 mL
5 mM	0.4287 mL	2.1435 mL	4.2871 mL	21.4353 mL
10 mM	0.2144 mL	1.0718 mL	2.1435 mL	10.7177 mL
20 mM	0.1072 mL	0.5359 mL	1.0718 mL	5.3588 mL
50 mM	0.0429 mL	0.2144 mL	0.4287 mL	2.1435 mL
100 mM	0.0214 mL	0.1072 mL	0.2144 mL	1.0718 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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