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BML-259

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Purity:99.68%

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COA HNMR HPLC

BML-259

Catalog No. T36964Cas No. 267654-00-2

BML-259 is an inhibitor of CDK5 and CDK2 with IC50s of 64 and 98 nM, respectively. BML-259 can be used in studies about the treatment of cancer and neurodegenerative diseases.

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Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$77	In Stock
25 mg	$172	In Stock
50 mg	$293	In Stock
100 mg	$513	In Stock
500 mg	$1,090	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Product Introduction

Bioactivity

Description	BML-259 is an inhibitor of CDK5 and CDK2 with IC50s of 64 and 98 nM, respectively. BML-259 can be used in studies about the treatment of cancer and neurodegenerative diseases.
In vitro	BML-259 prevents a large population of cells from NAC-evoked cell death[1].
Alias	CAY10554

Chemical Properties

Molecular Weight	260.35
Formula	C14H16N2OS
Cas No.	267654-00-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO:PBS (pH 7.2)(1:2): 0.3 mg/mL

DMF: 30 mg/mL

DMSO: 120 mg/mL (460.92 mM), Sonication is recommended.

Ethanol: 0.25 mg/mL

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8410 mL	19.2049 mL	38.4098 mL	192.0492 mL
5 mM	0.7682 mL	3.8410 mL	7.6820 mL	38.4098 mL
10 mM	0.3841 mL	1.9205 mL	3.8410 mL	19.2049 mL
20 mM	0.1920 mL	0.9602 mL	1.9205 mL	9.6025 mL
50 mM	0.0768 mL	0.3841 mL	0.7682 mL	3.8410 mL
100 mM	0.0384 mL	0.1920 mL	0.3841 mL	1.9205 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc