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CDK9-IN-28

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Catalog No. T79704

PROTAC CDK9/CycT1 Degrader-1 (compounds 10), a potent CDK9 inhibitor and target protein ligand for PROTAC synthesis, exhibits substantial anti-proliferative activity in solid tumors [1], making it instrumental in the targeted degradation of CDK9/CycT1.

CDK9-IN-28

CDK9-IN-28

😃Good
Catalog No. T79704
PROTAC CDK9/CycT1 Degrader-1 (compounds 10), a potent CDK9 inhibitor and target protein ligand for PROTAC synthesis, exhibits substantial anti-proliferative activity in solid tumors [1], making it instrumental in the targeted degradation of CDK9/CycT1.
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Product Introduction

Bioactivity
Description
PROTAC CDK9/CycT1 Degrader-1 (compounds 10), a potent CDK9 inhibitor and target protein ligand for PROTAC synthesis, exhibits substantial anti-proliferative activity in solid tumors [1], making it instrumental in the targeted degradation of CDK9/CycT1.
In vitro
CDK9-IN-28 exhibits pronounced CDK9 degradation in U-2932 cells and demonstrates significant antiproliferative activity in tumors [1].
In vivo
CDK9-IN-28 at a dosage of 5 mg/kg, administered intraperitoneally once daily for 15 consecutive days, exhibited tumor growth inhibition in the MV4-11 xenograft model in nude mice [1]. Additionally, CDK9-IN-28 demonstrated an acceptable half-life (T1/2: 4.66h) and moderate bioavailability (F=43.1%) at dosages of 1 mg/kg via intravenous and 5 mg/kg via intraperitoneal injection in the ICR (CD-1) mouse model.
Chemical Properties
Molecular Weight640.81
FormulaC32H40N4O6S2
Storage & Solubility Information
StorageShipping with blue ice.

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