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Pack Size | Price | Availability | Quantity |
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5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | PROTAC CDK9/CycT1 Degrader-1 (compounds 10), a potent CDK9 inhibitor, serves as a target protein ligand for PROTAC synthesis. Exhibiting substantial anti-proliferative activity in solid tumors [1], this compound is instrumental in the targeted degradation of CDK9/CycT1. |
In vitro | CDK9-IN-28 exhibits pronounced CDK9 degradation in U-2932 cells and demonstrates significant antiproliferative activity in tumors [1]. |
In vivo | CDK9-IN-28 at a dosage of 5 mg/kg, administered intraperitoneally once daily for 15 consecutive days, exhibited tumor growth inhibition in the MV4-11 xenograft model in nude mice [1]. Additionally, CDK9-IN-28 demonstrated an acceptable half-life (T1/2: 4.66h) and moderate bioavailability (F=43.1%) at dosages of 1 mg/kg via intravenous and 5 mg/kg via intraperitoneal injection in the ICR (CD-1) mouse model. |
Molecular Weight | 640.81 |
Formula | C32H40N4O6S2 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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