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NVP-2

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Purity:99.76%

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COA HNMR LCMS

NVP-2

Catalog No. T16363Cas No. 1263373-43-8

NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases (IC50: 0.584 μM, 0.706 μM, and 0.605 μM, respectively).

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Pack Size	Price	Availability
1 mg	$50	In Stock
2 mg	$72	In Stock
5 mg	$122	In Stock
10 mg	$213	In Stock
25 mg	$463	In Stock
50 mg	$683	In Stock
100 mg	$973	In Stock
1 mL x 10 mM (in DMSO)	$137	In Stock

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Product Introduction

Bioactivity

Description

In vitro

NVP-2 has an anti-proliferation of leukemia cells, suppresses KOPT-K1, Jurkat, P12-ICHIKAWA, DU.528, MOLT 16, HSB-2, PF-382, SKW-3, SUP-T11, DND-41 and HPB-ALL cells with IC50 values of 0.1688 μM, 0.1233 μM,0.5736 μM,0.1575 μM, 0.1620 μM,0.1585 μM, 0.1808 μM, 0.2589 μM, 0.0918 μM and 0.3023 μM, respectively. NVP-2 (0-10 nM; 72 hours) shows CRBN-dependent anti-proliferative and pro-apoptotic effects in MOLT4 cells (IC50: 9 nM). NVP-2 (250 nM; 24 hours) causes cell apoptosis in MOLT4 cells, upregulates caspase-3 and γH2A.X expression. However, while the compound washout significantly reduces the degree of apoptosis induced by NVP-2. NVP-2 (250 nM-1 μM; 6 hours) engages CDK9 in wildtype and CRBN?/? MOLT4 cells at all concentrations, while CDK2 and CDK7 are unaffected.

Chemical Properties

Molecular Weight	513.07
Formula	C27H37ClN6O2
Cas No.	1263373-43-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (194.91 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9491 mL	9.7453 mL	19.4905 mL	97.4526 mL
5 mM	0.3898 mL	1.9491 mL	3.8981 mL	19.4905 mL
10 mM	0.1949 mL	0.9745 mL	1.9491 mL	9.7453 mL
20 mM	0.0975 mL	0.4873 mL	0.9745 mL	4.8726 mL
50 mM	0.0390 mL	0.1949 mL	0.3898 mL	1.9491 mL
100 mM	0.0195 mL	0.0975 mL	0.1949 mL	0.9745 mL

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