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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $699 | In Stock |
Description | AG-024322 is a pan-CDK inhibitor with antitumor activity, induces apoptosis, and can be used in the study of metabolic diseases. |
Targets&IC50 | CDK4:2.9 nM (Ki), CDK1:2.3 nM (Ki), HCT116 cells:120 nM, CDK2:3 nM (ki), CDK4:2.9 nM (ki), CDK2:3 nM (Ki), CDK1:2.3 nM (ki) |
In vitro | Biotin-PEG4-Picolyl azide can utilize the ubiquitin-proteasome system to achieve selective elimination of target proteins through E3 ubiquitin ligase-mediated specific degradation of target proteins [1]. |
In vivo | In male and female cynomolgus monkeys, AG-024322 (at doses of 2, 6, and 10 mg/kg; intravenous infusion; over 5 days) resulted in dose-dependent pancytopenic bone marrow hypocellularity and lymphoid depletion in lymph nodes, spleen, and/or thymus at doses greater than 6 mg/kg[1]. |
Alias | AG 024322, AG024322, AG-024322 |
Molecular Weight | 418.44 |
Formula | C23H20F2N6 |
Cas No. | 837364-57-5 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (191.19 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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