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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $98 | In Stock | |
2 mg | $133 | In Stock | |
5 mg | $198 | In Stock | |
10 mg | $322 | In Stock | |
25 mg | $513 | In Stock | |
50 mg | $689 | In Stock | |
100 mg | $953 | In Stock | |
1 mL x 10 mM (in DMSO) | $226 | In Stock |
Description | Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM). |
In vitro | Senexin B inhibits CDK8/19 in low nanomolar range[1] |
In vivo | In a spleen-to-liver colon cancer metastasis model of syngeneic mouse CT26 tumors, Senexin B treatment of mice had the same effect as CDK8 knockdown in tumor cells: suppression of metastatic growth in the liver without a significant effect on primary tumor growth in the spleen[1]. |
Molecular Weight | 450.53 |
Formula | C27H26N6O |
Cas No. | 1449228-40-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
Solubility Information | DMSO: 6 mg/mL (13.32 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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