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5-Iodo-indirubin-3'-monoxime

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Catalog No. T10172Cas No. 331467-03-9

5-Iodo-indirubin-3'-monoxime is a potent inhibitor of GSK-3β, CDK5/P25, and CDK1/cyclin B, competing with ATP for binding to the catalytic site of the kinase (IC50s: 9, 20, and 25 nM).

5-Iodo-indirubin-3'-monoxime

5-Iodo-indirubin-3'-monoxime

😃Good
Catalog No. T10172Cas No. 331467-03-9
5-Iodo-indirubin-3'-monoxime is a potent inhibitor of GSK-3β, CDK5/P25, and CDK1/cyclin B, competing with ATP for binding to the catalytic site of the kinase (IC50s: 9, 20, and 25 nM).
Pack SizePriceAvailabilityQuantity
5 mg$2976-8 weeks
25 mg$9876-8 weeks
50 mg$1,3606-8 weeks
100 mg$1,8606-8 weeks
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Product Introduction

Bioactivity
Description
5-Iodo-indirubin-3'-monoxime is a potent inhibitor of GSK-3β, CDK5/P25, and CDK1/cyclin B, competing with ATP for binding to the catalytic site of the kinase (IC50s: 9, 20, and 25 nM).
Targets&IC50
GSK-3β:9 nM, CDK1-CyclinB:25 nM, CDK5-p25:20 nM
Chemical Properties
Molecular Weight403.17
FormulaC16H10IN3O2
Cas No.331467-03-9
SmilesO\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(I)cc12
Relative Density.1.99 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 66.7 mg/mL (165.43 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4803 mL12.4017 mL24.8034 mL124.0172 mL
5 mM0.4961 mL2.4803 mL4.9607 mL24.8034 mL
10 mM0.2480 mL1.2402 mL2.4803 mL12.4017 mL
20 mM0.1240 mL0.6201 mL1.2402 mL6.2009 mL
50 mM0.0496 mL0.2480 mL0.4961 mL2.4803 mL
100 mM0.0248 mL0.1240 mL0.2480 mL1.2402 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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