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5-Iodo-indirubin-3'-monoxime is a potent inhibitor of GSK-3β, CDK5/P25, and CDK1/cyclin B, competing with ATP for binding to the catalytic site of the kinase (IC50s: 9, 20, and 25 nM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $297 | 6-8 weeks | |
25 mg | $987 | 6-8 weeks | |
50 mg | $1,360 | 6-8 weeks | |
100 mg | $1,860 | 6-8 weeks |
Description | 5-Iodo-indirubin-3'-monoxime is a potent inhibitor of GSK-3β, CDK5/P25, and CDK1/cyclin B, competing with ATP for binding to the catalytic site of the kinase (IC50s: 9, 20, and 25 nM). |
Targets&IC50 | GSK-3β:9 nM, CDK1-CyclinB:25 nM, CDK5-p25:20 nM |
Molecular Weight | 403.17 |
Formula | C16H10IN3O2 |
Cas No. | 331467-03-9 |
Smiles | O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(I)cc12 |
Relative Density. | 1.99 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 66.7 mg/mL (165.43 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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