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T025

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Purity:98.08%

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COA HNMR HPLC

T025

Catalog No. T13058Cas No. 2407433-00-3

T025 is a pan CLK inhibitor with Kds of 4.8, 0.096, 6.5, 0.61, and 0.074 nM for CLK1-4, respectively. T025 displays anti-proliferative activities with IC50s of 30-300 nM in hematological and solid cancer cell lines. T025 can be used in studies about MYC-driven diseases.

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Pack Size	Price	Availability
1 mg	$146	In Stock
5 mg	$372	In Stock
10 mg	$556	In Stock
25 mg	$896	In Stock
50 mg	$1,220	In Stock
100 mg	$1,650	In Stock
500 mg	$3,290	In Stock
1 mL x 10 mM (in DMSO)	$397	In Stock

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Product Introduction

Bioactivity

Description	T025 is a pan CLK inhibitor with Kds of 4.8, 0.096, 6.5, 0.61, and 0.074 nM for CLK1-4, respectively. T025 displays anti-proliferative activities with IC50s of 30-300 nM in hematological and solid cancer cell lines. T025 can be used in studies about MYC-driven diseases.
In vitro	In MDA-MB-468 cells, T025 (1-1000 nM) dose-dependently suppresses cell growth and reduces pCLK2 and CLK2 phosphorylation levels[1].
In vivo	In Balb/c nude mice, gavage administration of T025 (50 mg/kg) suppresses tumor growth and < 10% nadir body weight loss. Gavage administration of T025 (50 mg/kg) inhibits the CLK-dependent phosphorylation and decreases the RPS6KB1 exon 7 and BCLAF1 exon 11 percentage splice-in values[1].

Chemical Properties

Molecular Weight	382.42
Formula	C21H18N8
Cas No.	2407433-00-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (26.15 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6149 mL	13.0746 mL	26.1493 mL	130.7463 mL
5 mM	0.5230 mL	2.6149 mL	5.2299 mL	26.1493 mL
10 mM	0.2615 mL	1.3075 mL	2.6149 mL	13.0746 mL
20 mM	0.1307 mL	0.6537 mL	1.3075 mL	6.5373 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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