CDK8-IN-1

Name: CDK8-IN-1
Brand: TargetMol
SKU: T10740
Price: 86 USD
Availability: InStock
Rating: 4.5 (1 reviews)

CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).

Catalog No. T10740Cas No. 1629633-48-2

Select Batch

Purity:97.09%

Resource Download

COA HNMR HPLC

CDK8-IN-1

Catalog No. T10740Cas No. 1629633-48-2

CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product information is being updated, if you want to purchase, please click the bulk custom button.

Bulk & Custom

Questions

Product Introduction

Bioactivity

Description	CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).
Targets&IC50	CDK8:3 nM
In vivo	CDK8-IN-1 exhibits low systemic clearance, excellent exposure, and oral bioavailability, with a tmax of 0.25 h (p.o.). The AUC values are 9378 (i.v.) and 25952 (p.o.), while the mean Cmax values are 9940 μg/L (i.v.) and 12740 μg/L (p.o.) respectively[1].

Chemical Properties

Molecular Weight	255.2
Formula	C₁₁H₈F₃N₃O
Cas No.	1629633-48-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 90 mg/mL (352.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9185 mL	19.5925 mL	39.1850 mL	195.9248 mL
5 mM	0.7837 mL	3.9185 mL	7.8370 mL	39.1850 mL
10 mM	0.3918 mL	1.9592 mL	3.9185 mL	19.5925 mL
20 mM	0.1959 mL	0.9796 mL	1.9592 mL	9.7962 mL
50 mM	0.0784 mL	0.3918 mL	0.7837 mL	3.9185 mL
100 mM	0.0392 mL	0.1959 mL	0.3918 mL	1.9592 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc