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CDK8-IN-13

CDK8-IN-13
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Purity:99.19%
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CDK8-IN-13

Catalog No. T72029Cas No. 918523-75-8
CDK8-IN-13 is a CDK8 inhibitor (IC50: 51.9 nM) with potent, selective and oral activity. CDK8-IN-13 induces apoptosis and reduces the expression of p-STAT1 S727 and p-STAT5 S726. CDK8-IN-13 exhibits anti-tumour activity.
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Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
5 mg$95In Stock
10 mg$139In Stock
25 mg$233In Stock
50 mg$349In Stock
100 mg$516In Stock
500 mg$1,090In Stock
1 mL x 10 mM (in DMSO)$88In Stock
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Product Introduction

Bioactivity
Description
CDK8-IN-13 is a CDK8 inhibitor (IC50: 51.9 nM) with potent, selective and oral activity. CDK8-IN-13 induces apoptosis and reduces the expression of p-STAT1 S727 and p-STAT5 S726. CDK8-IN-13 exhibits anti-tumour activity.
Targets&IC50
CDK8:51.9 nM
In vitro
CDK8-IN-13 (compound 43 ; 1, 2.5, 5, 10 µM ; 12 h) decreased p-STAT1 S727 and p-STAT5 S726 expression in HCT-116 cells in a dose-dependent manner.[1]
CDK8-IN-13 (0, 1, 5, 10 µM ; 48 h) induced apoptosis in a dose-dependent manner.[1]
In vivo
CDK8-IN-13 (40, 80 mg/kg ; orally ; for 15 days) inhibits tumor growth in a dose-dependent manner in mice.[1]
Chemical Properties
Molecular Weight237.26
FormulaC14H11N3O
Cas No.918523-75-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 112.5 mg/mL (474.2 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.2148 mL21.0739 mL42.1479 mL210.7393 mL
5 mM0.8430 mL4.2148 mL8.4296 mL42.1479 mL
10 mM0.4215 mL2.1074 mL4.2148 mL21.0739 mL
20 mM0.2107 mL1.0537 mL2.1074 mL10.5370 mL
50 mM0.0843 mL0.4215 mL0.8430 mL4.2148 mL
100 mM0.0421 mL0.2107 mL0.4215 mL2.1074 mL

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