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IC261

Catalog No. T2440Cas No. 186611-52-9
Alias SU-5607

IC261 (SU-5607) is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.

IC261

IC261

Purity: 99.86%
Catalog No. T2440Alias SU-5607Cas No. 186611-52-9
IC261 (SU-5607) is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.
Pack SizePriceAvailabilityQuantity
5 mg$64In Stock
10 mg$98In Stock
25 mg$189In Stock
50 mg$289In Stock
100 mg$428In Stock
500 mg$969In Stock
1 mL x 10 mM (in DMSO)$70In Stock
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Purity:99.86%
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Product Introduction

Bioactivity
Description
IC261 (SU-5607) is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.
Targets&IC50
CDK5:4.5 mM., CK1:16 μM
In vitro
IC261 leads to a p53-dependent arrest of the cells with a DNA content of 4 N. It can produce effects on cell cycle progression that are indistinguishable from an established spindle poison and are dependent on the p53 status of the cells[1].
In vivo
Intrathecal injection of a CK1 inhibitor IC261 attenuates neuropathic pain behaviors. CK1 inhibitors are found to be effective in reducing spinal excitatory response elicited by the presynaptic electrical stimulation only in neuropathic mice[2]. Targeting CK1 isoforms by IC261 influences both pancreatic tumour cell growth and apoptosis sensitivity in vitro and the growth of induced tumours in vivo[3].
Cell Research
Cultures of MEFs of di?erent genotypes (p53+/+, p53+/7, p537/7) are treated with the inhibitor IC261 in the low micromolar range (1 μM). After 12, 24, 48 hours exposure, the effects of IC261 on cell cycle distribution are measured by flow cytometry.(Only for Reference)
AliasSU-5607
Chemical Properties
Molecular Weight311.33
FormulaC18H17NO4
Cas No.186611-52-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 70 mg/mL (224.84 mM), Sonication is recommended.
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2120 mL16.0601 mL32.1203 mL160.6013 mL
5 mM0.6424 mL3.2120 mL6.4241 mL32.1203 mL
10 mM0.3212 mL1.6060 mL3.2120 mL16.0601 mL
20 mM0.1606 mL0.8030 mL1.6060 mL8.0301 mL
50 mM0.0642 mL0.3212 mL0.6424 mL3.2120 mL
100 mM0.0321 mL0.1606 mL0.3212 mL1.6060 mL

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