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XY028-140
XY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereblon and CDK.
Catalog No. T36694Cas No. 2229974-83-6
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Purity:98.59%
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XY028-140
Catalog No. T36694Cas No. 2229974-83-6
XY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereblon and CDK.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $34 | In Stock | |
| 5 mg | $80 | In Stock | |
| 10 mg | $128 | In Stock | |
| 25 mg | $263 | In Stock | |
| 50 mg | $422 | In Stock | |
| 100 mg | $628 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | XY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereblon and CDK. |
| In vitro | In A375 melanoma and T47D breast cancer cells, XY028-140(0.3 or 1 µΜ for 24h) inhibited both CDK4/6 expression and CDK4/6 activity. In T47D breast cancer cells, XY028-140(0.03, 0.1, 0.3, 1, or 3 µΜ for 11d) inhibited cancer cell proliferation in breast cancer cells[1]. |
| Alias | XY028-140 |
| Molecular Weight | 760.8 |
| Formula | C39H40N10O7 |
| Cas No. | 2229974-83-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (6.57 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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