Shopping Cart

Remove All

Your shopping cart is currently empty

PF-06873600

Select Batch

Purity:99.36%

Resource Download

COA HNMR HPLC

PF-06873600

Catalog No. T8463Cas No. 2185857-97-8

PF-06873600 is a selective and orally bioavailable cyclin-dependent kinase (CDK) inhibitor(CDK2, CDK4 and CDK6 with Ki of 0.09 nM, 0.13 nM and 0.16 nM, respectively), has potential antineoplastic activity.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$113	In Stock
5 mg	$282	In Stock
10 mg	$448	In Stock
25 mg	$847	In Stock
50 mg	$1,130	In Stock
100 mg	$1,530	In Stock
500 mg	$2,970	In Stock
1 mL x 10 mM (in DMSO)	$349	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "PF-06873600"

Product Introduction

Bioactivity

Description	PF-06873600 is a selective and orally bioavailable cyclin-dependent kinase (CDK) inhibitor(CDK2, CDK4 and CDK6 with Ki of 0.09 nM, 0.13 nM and 0.16 nM, respectively), has potential antineoplastic activity.
In vitro	PF-06873600 selectively targets, binds to and inhibits the activity of CDKs.?Inhibition of these kinases leads to cell cycle arrest, induction of apoptosis and inhibition of tumor cell proliferation.?CDKs, ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and cellular proliferation, are frequently overexpressed in tumor cells.

Chemical Properties

Molecular Weight	471.52
Formula	C20H27F2N5O4S
Cas No.	2185857-97-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.33 mg/mL (176.73 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1208 mL	10.6040 mL	21.2080 mL	106.0400 mL
5 mM	0.4242 mL	2.1208 mL	4.2416 mL	21.2080 mL
10 mM	0.2121 mL	1.0604 mL	2.1208 mL	10.6040 mL
20 mM	0.1060 mL	0.5302 mL	1.0604 mL	5.3020 mL
50 mM	0.0424 mL	0.2121 mL	0.4242 mL	2.1208 mL
100 mM	0.0212 mL	0.1060 mL	0.2121 mL	1.0604 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc