Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $168 | In Stock | |
5 mg | $419 | In Stock | |
10 mg | $679 | In Stock | |
25 mg | $1,390 | In Stock | |
50 mg | $2,190 | In Stock | |
100 mg | $2,970 | In Stock | |
1 mL x 10 mM (in DMSO) | $463 | In Stock |
Description | CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer. |
Targets&IC50 | CDK9-cyclinT1:127 μM, CDK12:23.9 nM, CDK2-CyclinE:173 μM |
In vitro | CDK12-IN-5 (Example 426) selectively suppresses BRCA1 mRNA levels in MDA-MB-231 cells (IC50 = 3.23 nM) without affecting CAL-120 cells. It exhibits antiproliferative effects on both MDA-MB-231 (IC50 = 4.19 nM) and CAL-120 cells (IC50 = 3.57 nM). Additionally, CDK12-IN-5 demonstrates high selectivity for CDK12 inhibition with an IC50 to DC50 CDK12 ratio of 32[1]. |
Molecular Weight | 454.36 |
Formula | C18H15F5N8O |
Cas No. | 2651200-35-8 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (220.09 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.