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CDK12-IN-5

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Purity:99.37%

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COA HNMR HPLC

CDK12-IN-5

Catalog No. T40290Cas No. 2651200-35-8

CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$168	In Stock
5 mg	$419	In Stock
10 mg	$679	In Stock
25 mg	$1,390	In Stock
50 mg	$2,190	In Stock
100 mg	$2,970	In Stock
1 mL x 10 mM (in DMSO)	$463	In Stock

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Product Introduction

Bioactivity

Description	CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.
Targets&IC50	CDK9-cyclinT1:127 μM, CDK12:23.9 nM, CDK2-CyclinE:173 μM
In vitro	CDK12-IN-5 (Example 426) selectively suppresses BRCA1 mRNA levels in MDA-MB-231 cells (IC50 = 3.23 nM) without affecting CAL-120 cells. It exhibits antiproliferative effects on both MDA-MB-231 (IC50 = 4.19 nM) and CAL-120 cells (IC50 = 3.57 nM). Additionally, CDK12-IN-5 demonstrates high selectivity for CDK12 inhibition with an IC50 to DC50 CDK12 ratio of 32[1].

Chemical Properties

Molecular Weight	454.36
Formula	C18H15F5N8O
Cas No.	2651200-35-8

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (220.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2009 mL	11.0045 mL	22.0090 mL	110.0449 mL
5 mM	0.4402 mL	2.2009 mL	4.4018 mL	22.0090 mL
10 mM	0.2201 mL	1.1004 mL	2.2009 mL	11.0045 mL
20 mM	0.1100 mL	0.5502 mL	1.1004 mL	5.5022 mL
50 mM	0.0440 mL	0.2201 mL	0.4402 mL	2.2009 mL
100 mM	0.0220 mL	0.1100 mL	0.2201 mL	1.1004 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc