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MC180295
🥰Excellent
Catalog No. T5533Cas No. 2237942-08-2
Alias (rel)-MC180295
MC180295 ((rel)-MC180295) is a novel, potent, and highly selective CDK9 inhibitor with an IC50 of 5 nM, demonstrating over 22-fold selectivity compared to other CDKs.
MC180295
🥰Excellent
Purity: 99.84%
Catalog No. T5533Alias (rel)-MC180295Cas No. 2237942-08-2
MC180295 ((rel)-MC180295) is a novel, potent, and highly selective CDK9 inhibitor with an IC50 of 5 nM, demonstrating over 22-fold selectivity compared to other CDKs.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $51 | In Stock | |
| 5 mg | $133 | In Stock | |
| 10 mg | $197 | In Stock | |
| 25 mg | $335 | In Stock | |
| 50 mg | $472 | In Stock | |
| 100 mg | $672 | In Stock | |
| 200 mg | $886 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $146 | In Stock |
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Purity:99.84%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | MC180295 ((rel)-MC180295) is a novel, potent, and highly selective CDK9 inhibitor with an IC50 of 5 nM, demonstrating over 22-fold selectivity compared to other CDKs. |
| Targets&IC50 | CDK5-p25:186 nM (cell free), CDK5-p35:159 nM (cell free), CDK9-CyclinT1:5 nM (cell free), CDK4-Cyclin D:112 nM (cell free), CDK1-CyclinB:138 nM (cell free) |
| In vitro | MC180295 is a potent, selective CDK9-Cyclin T1 inhibitor with an IC50 of 5 nM, displaying at least 22-fold selectivity over other CDKs, including CDK1-Cyclin B (IC50, 138 nM), CDK2-Cyclin A (IC50, 233 nM), CDK2-Cyclin E (IC50, 367 nM), CDK3-Cyclin E (IC50, 399 nM), CDK4-Cyclin D (IC50, 112 nM), CDK5-P35 (IC50, 159 nM), and CDK5-P25 (IC50, 186 nM). MC180295 (0.1 μM) demonstrates broad anti-cancer activity in vitro. |
| In vivo | MC180295 (20 mg/kg, i.p., qod) demonstrates significant anti-tumor activity in mice with SW48 cells without inhibiting human T cell growth in vivo. |
| Alias | (rel)-MC180295 |
| Molecular Weight | 358.41 |
| Formula | C17H18N4O3S |
| Cas No. | 2237942-08-2 |
| Smiles | Nc1nc(N[C@H]2C[C@@H]3CC[C@H]2C3)sc1C(=O)c1ccccc1[N+]([O-])=O |
| Relative Density. | 1.462 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 70 mg/mL (195.31 mM ) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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