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JSH-150

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Purity:100%

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COA HPLC HNMR

JSH-150

Catalog No. T8484Cas No. 2247481-21-4

JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).

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Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$89	In Stock
10 mg	$156	In Stock
25 mg	$347	In Stock
50 mg	$538	In Stock
100 mg	$651	In Stock
500 mg	$1,390	In Stock

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Product Introduction

Bioactivity

Description	JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).
In vitro	A highly selective inhibitor compound 40 (JSH-150), which exhibited an IC50 of 1 nM against CDK9 kinase in the biochemical assay and achieved around 300 10000-fold selectivity over other CDK kinase family members.?In addition, it also displayed high selectivity over other 468 kinases/mutants (KINOMEscan S score(1) = 0.01).Compound 40 displayed potent antiproliferative effects against melanoma, neuroblastoma, hepatoma, colon cancer, lung cancer as well as leukemia cell lines.?It could dose-dependently inhibit the phosphorylation of RNA Pol II, suppress the expression of MCL-1 and c-Myc, arrest the cell cycle and induce the apoptosis in the leukemia cells.
In vivo	In the MV4-11 cell-inoculated xenograft mouse model, 10 mg/kg dosage of 40 could almost completely suppress the tumor progression.?The high selectivity and good in vivo PK/PD profile suggested that 40 would be a good pharmacological tool to study CDK9-mediated physiology and pathology as well as a potential drug candidate for leukemia and other cancers.

Chemical Properties

Molecular Weight	505.08
Formula	C24H33ClN6O2S
Cas No.	2247481-21-4

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (108.89 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9799 mL	9.8994 mL	19.7988 mL	98.9942 mL
5 mM	0.3960 mL	1.9799 mL	3.9598 mL	19.7988 mL
10 mM	0.1980 mL	0.9899 mL	1.9799 mL	9.8994 mL
20 mM	0.0990 mL	0.4950 mL	0.9899 mL	4.9497 mL
50 mM	0.0396 mL	0.1980 mL	0.3960 mL	1.9799 mL
100 mM	0.0198 mL	0.0990 mL	0.1980 mL	0.9899 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc