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CDK9-IN-12
🥰Excellent
Catalog No. T39354Cas No. 1942843-54-0
CDK9-IN-12 is a highly selective CDK9 inhibitor, which is commonly used in leukemia research to regulate oncogene expression, inhibit oncogenic proliferation, and induce apoptosis by targeting CDK9-dependent transcription processes.
CDK9-IN-12
🥰Excellent
Purity: 98.93%
Catalog No. T39354Cas No. 1942843-54-0
CDK9-IN-12 is a highly selective CDK9 inhibitor, which is commonly used in leukemia research to regulate oncogene expression, inhibit oncogenic proliferation, and induce apoptosis by targeting CDK9-dependent transcription processes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $397 | In Stock | |
| 5 mg | $970 | In Stock | |
| 10 mg | $1,290 | In Stock | |
| 25 mg | $1,950 | In Stock | |
| 50 mg | $2,620 | In Stock |
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CitedSelect Batch
Purity:98.93%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CDK9-IN-12 is a highly selective CDK9 inhibitor, which is commonly used in leukemia research to regulate oncogene expression, inhibit oncogenic proliferation, and induce apoptosis by targeting CDK9-dependent transcription processes. |
| Targets&IC50 | CDK9-CyclinT1:5.41 nM |
| In vitro | CDK9-IN-12 has an inhibitory effect on the following cells: Mino, Z-138, JeKo-1, Raji, OCI-Ly-10, TMD8, MM.1S, RPMI-8226, Kasumi-1, HL-60, CCRF-CEM, MV-4-11 cells with IC50 values of 8.4, 46, 46, 37, 3.2, 46, 1.5, 5.4, 21, 44, 2.1, 1.6 nM, respectively. [1] |
| In vivo | Methods: CDK9-IN-12 (7.5 mg/kg, 0.5% CMC-Na, gavage, 21 days) was used to treat MV-4-11 cell tumor xenograft model mice. First, PK experiments were performed in mice. Second, the diameter of the transplanted tumor and the weight of the mice were measured twice a week to evaluate the in vivo anticancer effect. Results: CDK9-IN-12 has a long half-life (t1/2 = 8.02 h) and acceptable bioavailability (F = 33.7%). In addition, CDK9-IN-12 can significantly inhibit tumor progression, with a T/C value of 27.80%. [1] |
| Molecular Weight | 378.86 |
| Formula | C21H19ClN4O |
| Cas No. | 1942843-54-0 |
| Smiles | ClC1=C(C=2C=C3C(=CC2)NN=C3C)C=C(N[C@@H](CO)C4=CC=CC=C4)C=N1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (211.16 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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