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Atuveciclib S-Enantiomer

Catalog No. T10465Cas No. 2250279-81-1

Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is the (S)-enantiomer of BAY-1143572. Atuveciclib S-Enantiomer is a potent and selective CDK9 inhibitor, which inhibits CDK9 / CycT1 with an IC 50 of 16 nM.

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Pack Size	Price	Availability
25 mg	$2,258	6-8 weeks
50 mg	Inquiry	6-8 weeks
100 mg	Inquiry	6-8 weeks

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Product Introduction

Bioactivity

Description	Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is the (S)-enantiomer of BAY-1143572. Atuveciclib S-Enantiomer is a potent and selective CDK9 inhibitor, which inhibits CDK9 / CycT1 with an IC 50 of 16 nM.
In vitro	Atuveciclib (BAY-1143572) S-Enantiomer reveals very similar in vitro properties compared with Atuveciclib (BAY-1143572), well within the limits of measurement accuracy. However, with multiple batches of Atuveciclib (BAY-1143572) S-Enantiomer, there is a trend toward a slightly lower activity against CDK9 in the biochemical assay (IC 50 CDK9/CycT1: 16 nM) and antiproliferative activity against HeLa cells (IC 50 : 1100 nM) [1].
In vivo	Atuveciclib (BAY-1143572) S-Enantiomer exhibits blood/plasma ratios close to 1, suggesting a similarity in distribution. Compared to its parent compound, Atuveciclib (BAY-1143572), this enantiomer demonstrates comparable pharmacokinetic (PK) properties in rats, including a clearance rate (CL b) of 1.2 L/kg per hour, a steady-state volume of distribution (V ss) of 1.2 L/kg, a half-life (t 1/2) of 0.6 hours, and a bioavailability (F) of 53% [1].
Alias	BAY-1143572 S-Enantiomer

Chemical Properties

Molecular Weight	387.43
Formula	C18H18FN5O2S
Cas No.	2250279-81-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 113 mg/mL (291.67 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5811 mL	12.9056 mL	25.8111 mL	129.0556 mL
5 mM	0.5162 mL	2.5811 mL	5.1622 mL	25.8111 mL
10 mM	0.2581 mL	1.2906 mL	2.5811 mL	12.9056 mL
20 mM	0.1291 mL	0.6453 mL	1.2906 mL	6.4528 mL
50 mM	0.0516 mL	0.2581 mL	0.5162 mL	2.5811 mL
100 mM	0.0258 mL	0.1291 mL	0.2581 mL	1.2906 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc