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Atuveciclib S-Enantiomer
Catalog No. T10465Cas No. 2250279-81-1
Alias BAY-1143572 S-Enantiomer
Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is a potent and selective CDK9 inhibitor, inhibiting CDK9/CycT1 with an IC50 of 16 nM.
Atuveciclib S-Enantiomer
Atuveciclib S-Enantiomer
Catalog No. T10465Alias BAY-1143572 S-EnantiomerCas No. 2250279-81-1
Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is a potent and selective CDK9 inhibitor, inhibiting CDK9/CycT1 with an IC50 of 16 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $2,258 | 6-8 weeks | |
| 50 mg | Inquiry | 6-8 weeks | |
| 100 mg | Inquiry | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is a potent and selective CDK9 inhibitor, inhibiting CDK9/CycT1 with an IC50 of 16 nM. |
| Targets&IC50 | CDK9-CyclinT1:16 nM |
| In vitro | Atuveciclib (BAY-1143572) S-Enantiomer reveals very similar in vitro properties compared with Atuveciclib (BAY-1143572), well within the limits of measurement accuracy. However, with multiple batches of Atuveciclib (BAY-1143572) S-Enantiomer, there is a trend toward a slightly lower activity against CDK9 in the biochemical assay (IC 50 CDK9/CycT1: 16 nM) and antiproliferative activity against HeLa cells (IC 50 : 1100 nM) [1]. |
| In vivo | Atuveciclib (BAY-1143572) S-Enantiomer shows blood/plasma ratios close to 1, indicating similar distribution. It has comparable pharmacokinetic properties to its parent compound in rats, with a clearance rate (CL b) of 1.2 L/kg per hour, a steady-state volume of distribution (V ss) of 1.2 L/kg, a half-life (t 1/2) of 0.6 hours, and a bioavailability (F) of 53% [1]. |
| Alias | BAY-1143572 S-Enantiomer |
| Molecular Weight | 387.43 |
| Formula | C18H18FN5O2S |
| Cas No. | 2250279-81-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 113 mg/mL (291.67 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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