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(R)-Atuveciclib
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Catalog No. T10464Cas No. 2923012-24-0
Alias BAY-1143572
(R)-Atuveciclib is an isomer of Atuveciclib. Atuveciclib (BAY 1143572) is a potent and highly selective PTEFb/CDK9 inhibitor with an IC50 value of 13 nm for CDK9/CycT1 and a selectivity ratio of 100 for CDK2, with highly bioavailable and orally available advantages.
(R)-Atuveciclib
😃Good
Catalog No. T10464Alias BAY-1143572Cas No. 2923012-24-0
(R)-Atuveciclib is an isomer of Atuveciclib. Atuveciclib (BAY 1143572) is a potent and highly selective PTEFb/CDK9 inhibitor with an IC50 value of 13 nm for CDK9/CycT1 and a selectivity ratio of 100 for CDK2, with highly bioavailable and orally available advantages.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 mg | $1,510 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | (R)-Atuveciclib is an isomer of Atuveciclib. Atuveciclib (BAY 1143572) is a potent and highly selective PTEFb/CDK9 inhibitor with an IC50 value of 13 nm for CDK9/CycT1 and a selectivity ratio of 100 for CDK2, with highly bioavailable and orally available advantages. |
| Targets&IC50 | CDK5-p35:1600 nM, CDK9-CyclinT1:13 nM, CDK9-CyclinT1:6 nM, CDK1-CyclinB:1100 nM, CDK2-CyclinE:1000 nM, CDK3-CyclinE:890 nM |
| Alias | BAY-1143572 |
| Molecular Weight | 387.43 |
| Formula | C18H18FN5O2S |
| Cas No. | 2923012-24-0 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 128.5 mg/mL (331.67 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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