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Cirtuvivint
🥰Excellent
Catalog No. T39608Cas No. 2143917-62-6
Alias SM08502
Cirtuvivint (SM08502) is a potent, orally active CDC-like kinase (CLK) inhibitor useful for the study of arthritis.
Cirtuvivint
🥰Excellent
Purity: 100%
Catalog No. T39608Alias SM08502Cas No. 2143917-62-6
Cirtuvivint (SM08502) is a potent, orally active CDC-like kinase (CLK) inhibitor useful for the study of arthritis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $107 | In Stock | |
| 5 mg | $263 | In Stock | |
| 10 mg | $396 | In Stock | |
| 25 mg | $793 | In Stock | |
| 50 mg | $1,130 | In Stock | |
| 100 mg | $1,520 | In Stock | |
| 500 mg | $2,970 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Cirtuvivint (SM08502) is a potent, orally active CDC-like kinase (CLK) inhibitor useful for the study of arthritis. |
| In vitro | Inhibiting serine and arginine-rich splicing factor (SRSF) phosphorylation and disrupting spliceosome activity, Cirtuvivint (SM08502) is associated with the inhibition of Wnt pathway-related gene and protein expression. Cirtuvivint induces the generation of splicing variants of Wnt pathway genes, suggesting that its mechanism for inhibiting gene expression includes effects on alternative splicing[1]. |
| In vivo | Significantly inhibiting the growth of gastrointestinal tumors, orally administered Cirtuvivint (SM08502) decreases SRSF phosphorylation and Wnt pathway gene expression in xenograft mouse models[1]. |
| Alias | SM08502 |
| Molecular Weight | 427.5 |
| Formula | C24H25N7O |
| Cas No. | 2143917-62-6 |
| Smiles | CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 6 mg/mL (14.04 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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