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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $72 | In Stock | |
5 mg | $113 | In Stock | |
10 mg | $178 | In Stock | |
25 mg | $319 | In Stock | |
50 mg | $513 | In Stock | |
100 mg | $747 | In Stock | |
1 mL x 10 mM (in DMSO) | $97 | In Stock |
Description | ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression. |
In vitro | ON 013100 effectively inhibits the proliferation of various cancer cell lines, including mantle cell lymphoma (MCL; JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, FLO-1) at nanomolar concentrations (ON 013100 GI50=6.7-11.2 nM). It significantly modifies the cell cycle distribution, notably increasing the population of cells at the G2/M phase, with treatment at just 0.1 μM leading to G2/M phase arrest. Additionally, ON-013100 triggers apoptosis, demonstrating broad-spectrum anti-cancer activity in vitro[2][3]. |
Molecular Weight | 394.44 |
Formula | C19H22O7S |
Cas No. | 865783-95-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (63.38 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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