Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on the N-terminal of the core histones.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 29.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 29.00 |
Description | Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on the N-terminal of the core histones. |
Targets&IC50 | HDAC1:0.25 μm (JK cell), HDAC3:0.3 μm (JK cell) |
In vitro | In MEL cells, SBHA leads to the accumulation of acetylated H4, indicating the hydroxamic acid groups are involved in increasing potency and inhibition of HDAC activity. In Jurkat cells, SHBA inhibits the HDAC1 and HDAC3 activities with IC50 value of 0.25 and 0.3 μm respectively. |
Synonyms | SBHA, Suberohydroxamic acid |
Molecular Weight | 204.22 |
Formula | C8H16N2O4 |
CAS No. | 38937-66-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 8.16 mg/mL (40 mM), Sonication is recommended.
DMSO: 49 mg/mL (239.93 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Suberoyl bis-hydroxamic acid 38937-66-5 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair HDAC MTC inhibit Histone deacetylases Malignant carcinoma neoplastic disease SBHA neuroendocrine malignancy neoplasia mesothelioma Suberohydroxamic acid Suberoyl bishydroxamic acid thyroid Inhibitor Medullary Suberoyl bis hydroxamic acid inhibitor