Powder: -20°C for 3 years | In solvent: -80°C for 1 year
11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenase
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 55.00 | |
5 mg | In stock | $ 139.00 | |
10 mg | In stock | $ 222.00 | |
25 mg | In stock | $ 375.00 | |
50 mg | In stock | $ 553.00 | |
100 mg | In stock | $ 789.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 143.00 |
Description | 11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenase |
In vitro | A total of ten transformed compounds were isolated and purified, and their chemical structures were characterized as 7β-hydroxy-11-keto-β-boswellic acid; 7β, 15α±-dihydroxy-11-keto-β-boswellic acid ; 7β, 16β-dihydroxy-11-keto-β-boswellic acid; 7β, 16α±-dihydroxy-11-keto-β-boswellic acid; 7β, 22β-dihydroxy-11-keto-β-boswellic acid; 7β, 21β-dihydroxy-11-keto-β-boswellic acid; 7β, 20β-dihydroxy-11-keto-β-boswellic acid; 7β, 30-dihydroxy-11-keto-β-boswellic acid; 3α±, 7β-dihydroxy-11-oxours-12-ene-24, 30-dioic acid and 3α±, 7β-dihydroxy-30-(2-hydroxypropanoyloxy)-11-oxours-12-en-24-oic acid by various spectroscopic methods. The biotransformation processes include hydroxylation, oxidation and esterification. Primary structure-activity relationships (SAR) of inhibitory effects on NO production in RAW 264.7 macrophage cells are discussed[1] |
Source |
Synonyms | 11-Keto-beta-boswellic acid |
Molecular Weight | 470.68 |
Formula | C30H46O4 |
CAS No. | 17019-92-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (47.8 mM)
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11-Keto-beta-boswellic acid 17019-92-0 GPCR/G Protein Metabolism NF-Κb Leukotriene Receptor NF-κB Lipoxygenase 11-Keto-β-boswellic acid LOX Inhibitor 11 Keto beta boswellic acid Nuclear factor-κB Nuclear factor-kappaB 11Ketobetaboswellic acid 11-Keto-beta-boswellic acid inhibit 11-Keto-b-boswellic acid inhibitor