Dehydrogenase

A dehydrogenase (also called DH or DHase in the literature) is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN. They also catalyze the reverse reaction, for instance alcohol dehydrogenase not only oxidizes ethanol to acetaldehyde in animals but also produces ethanol from acetaldehyde in yeast.

Cat. No.	Product name	CAS No.	Purity
T10160	11β-HSD1-IN-1	1203956-47-1	98%
T10160	11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1, IC50: 52 nM), and used for the treatment of pain.
T27214	DSM421	2011769-21-2	98%
T27214	DSM421 is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shown activity against ...
T60240	ALDH1A3-IN-2	886502-08-5	98%
T60240	ALDH1A3-IN-2 is a potent ALDH1A3 inhibitor with an IC50 of 0.30 μM.ALDH1A3-IN-2 has potential for cancer disease research.
T25209	CB29	315239-63-5	98%
T25209	CB29 is a specific inhibitor of aldehyde dehydrogenase 3A1 (ALDH3A1).
T67903	1-(biphenyl-4-ylsulfonyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine	946394-50-9	98%
T67903	1-(biphenyl-4-ylsulfonyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).
T67832	ALDH2 modulator 1	1629615-99-1	98%
T67832	ALDH2 modulator 1 is a potent and orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.
T25006	AGI-14100	1448346-43-7	98%
T25006	AGI-14100 is a novel and orally available mIDH1 inhibitor.AGI-14100 is used for the treatment of primary human myeloid leukemia.
T60364	DHODH-IN-17	16344-26-6	98%
T60364	DHODH-IN-17 is a human DHODH inhibitor with an IC50 of 0.40 μM. DHODH-IN-17 is a 2- anilino nicotinic acid that can be used in the study of acute myeloid leukemi...
T73143	PHGDH-IN-3	2893778-31-7	98%
T73143	PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH. PHGDH-IN-3 can be used in studies about can...
T3044	(E/Z)-Teriflunomide	108605-62-5	98%
T3044	Teriflunomide, a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.
T7732	Carbenoxolone	5697-56-3	98%
T7732	Carbenoxolone is an inhibitor of 11β-HSD and gap junction connexin channels. Carbenoxolone inhibits macrophage migration into atria and prevents the development ...
T2637	ADH-1	229971-81-7	98%
T2637	Exherin (ADH-1) is an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion with potential antineoplastic and antiangiogenic activities.
T64360	HDHODH-IN-8	2757405-31-3	98%
T64360	hDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 16 nM. hDHODH-IN-8 has potent antiproliferative activity and exc...
T14780	BRD9185	2057420-29-6	98%
T14780	BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.
T16269	Nanaomycin A	52934-83-5	98%
T16269	Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 5...
T11611	IDH1 Inhibitor 2	2244895-42-7	98%
T11611	IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).
T12663	(Rac)-BMS-816336	T12663	98%
T12663	(Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzym...
T11238	Etamicastat	760173-05-5	98%
T11238	Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor wit...
T14383	AZD8329	1048668-70-7	98%
T14383	AZD8329 is a selectable and potent inhibitor of human recombinant 11β-HSD1 and isolated human adipocyte 11ß-HSD1 and is an inhibitor of rat 11β-HSD1 (IC50 - 89nM...
T13054	T-3764518	1809151-56-1	98%
T13054	T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).