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Dehydrogenase

A dehydrogenase (also called DH or DHase in the literature) is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN. They also catalyze the reverse reaction, for instance alcohol dehydrogenase not only oxidizes ethanol to acetaldehyde in animals but also produces ethanol from acetaldehyde in yeast.
Cat No. product name
T40168 DHODH-IN-16 DHODH-IN-16 是一种有效的二氢乳清酸脱氢酶抑制剂(DHODH,IC50 = 0.396 nM)。
T0414 D-Mannitol Mannitol is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any ...
T0972 Isoniazid Isoniazid is an antibacterial agent used primarily as a tuberculostatic.
T1869 PluriSIn 1 PluriSln 1(NSC 14613) is an inhibitor of stearoyl-CoA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism ...
T2901 Daidzin Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
T1717 Alpha-Mangostin Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
T4515 A939572 A939572 is stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM for mSCD1 and 37 nM for hSCD1.
T3494 LW6 LW6 is a novel HIF-1 inhibitor.
T0684 Ribavirin Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
T12574 PTC299 PTC299 is a orally bioavailable inhibitor of VEGFA.
T5S0620 3-Dehydrotrametenolic acid 1. Dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor. 2. Dehydrotrametenolic acid is a promising candidate for a new t...
T0647 Tryptamine Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It ...
T3617 Ivosidenib Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a...
T2741 Glycyrrhizic acid Glycyrrhizic acid is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.
T1485 Methotrexate Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties.
T10525 SCD1 inhibitor-4 SCD1 inhibitor-4 is stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.
T11020 DHODH-IN-11 DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
T11546 HDHODH-IN-1 hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor with an anti-inflammatory effect.
T0293 Metyrapone Metyrapone is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of...
T1159 Leflunomide Leflunomide is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
T2601 Vidofludimus Vidofludimus (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
T22350 JX06 JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.
T13019 Succinyl phosphonate trisodium salt Succinyl phosphonate trisodium salt is an inhibitor of α-ketoglutarate dehydrogenase (KGDHC)
T1919 Tenovin-1 Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
T2346 Enasidenib Enasidenib is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineopl...
T6518 Gossypol Gossypol Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
T1818 Tenovin-6 Tenovin-6 is a p53 transcriptional activity agonist.
T16384 Olutasidenib Olutasidenib is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain pen...
T5013 Brequinar Brequinar is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
T17224 VER-246608 VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK...
T16161 Mutant IDH1 inhibitor Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).
T4S0878 Prunetin 1. Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obes...
T1491 Atovaquone Atovaquone is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.
T0256 Citric acid trilithium salt tetrahydrate Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and me...
T1809 AGI-6780 AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
T0036 18β-Glycyrrhetinic acid Enoxolone is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
T4778 3-Hydroxybenzaldehyde 3-Hydroxybenzaldehyde is a compound useful in organic synthesis.
T4382 Proguanil hydrochloride Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted ...
T2970 Rotenone Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papilionoideae)....
T16277 NCT-502 NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-derived serine production an...
T5427 GSK1940029 GSK1940029 is a stearoyl-coa desaturase (SCD) inhibitor.
T1165 Ethionamide Ethionamide is a nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unkno...
T3444 Merimepodib Merimepodib is a novel noncompetitive inhibitor of Inosine monophosphate dehydrogenase(IMPDH).
T9594 BI-187004 BI-187004 is an 11β-hydroxysteroid dehydrogenase 1 inhibitor.
T5325 Nifurtimox Nifurtimox is an antiprotozoal agent (IC50s = 9.91, 12.28, and 10.44 μM against Taluahuén, LQ, and Brener strains of T. cruzi­ epimastigotes, respectively).
T3009 3-Nitropropanoic acid Bovinocidin is an irreversible inhibitor of succinate dehydrogenase.
T10148 4-Hydroxynonenal 4-Hydroxynonenal (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).
T3019 Physcion Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenas...
T6293 Mycophenolate Mofetil Mycophenolate mofetil, an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydroge...
T13356 XEN723 XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).
DHODH-IN-16
T40168
DHODH-IN-16 是一种有效的二氢乳清酸脱氢酶抑制剂(DHODH,IC50 = 0.396 nM)。
D-Mannitol
T0414
Mannitol is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any ...
Isoniazid
T0972
Isoniazid is an antibacterial agent used primarily as a tuberculostatic.
PluriSIn 1
T1869
PluriSln 1(NSC 14613) is an inhibitor of stearoyl-CoA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism ...
Daidzin
T2901
Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
alpha-Mangostin
T1717
Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
A939572
T4515
A939572 is stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM for mSCD1 and 37 nM for hSCD1.
LW6
T3494
LW6 is a novel HIF-1 inhibitor.
Ribavirin
T0684
Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
PTC299
T12574
PTC299 is a orally bioavailable inhibitor of VEGFA.
3-Dehydrotrametenolic acid
T5S0620
1. Dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor. 2. Dehydrotrametenolic acid is a promising candidate for a new t...
Tryptamine
T0647
Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It ...
Ivosidenib
T3617
Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a...
Glycyrrhizic acid
T2741
Glycyrrhizic acid is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.
Methotrexate
T1485
Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties.
SCD1 inhibitor-4
T10525
SCD1 inhibitor-4 is stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.
DHODH-IN-11
T11020
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
hDHODH-IN-1
T11546
hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor with an anti-inflammatory effect.
Metyrapone
T0293
Metyrapone is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of...
Leflunomide
T1159
Leflunomide is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
Vidofludimus
T2601
Vidofludimus (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
JX06
T22350
JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.
Succinyl phosphonate trisodium salt
T13019
Succinyl phosphonate trisodium salt is an inhibitor of α-ketoglutarate dehydrogenase (KGDHC)
Tenovin-1
T1919
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
Enasidenib
T2346
Enasidenib is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineopl...
Gossypol
T6518
Gossypol Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
Tenovin-6
T1818
Tenovin-6 is a p53 transcriptional activity agonist.
Olutasidenib
T16384
Olutasidenib is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain pen...
Brequinar
T5013
Brequinar is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
VER-246608
T17224
VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK...
Mutant IDH1 inhibitor
T16161
Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).
Prunetin
T4S0878
1. Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obes...
Atovaquone
T1491
Atovaquone is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.
Citric acid trilithium salt tetrahydrate
T0256
Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and me...
AGI-6780
T1809
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
18β-Glycyrrhetinic acid
T0036
Enoxolone is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
3-Hydroxybenzaldehyde
T4778
3-Hydroxybenzaldehyde is a compound useful in organic synthesis.
Proguanil hydrochloride
T4382
Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted ...
Rotenone
T2970
Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papilionoideae)....
NCT-502
T16277
NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-derived serine production an...
GSK1940029
T5427
GSK1940029 is a stearoyl-coa desaturase (SCD) inhibitor.
Ethionamide
T1165
Ethionamide is a nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unkno...
Merimepodib
T3444
Merimepodib is a novel noncompetitive inhibitor of Inosine monophosphate dehydrogenase(IMPDH).
BI-187004
T9594
BI-187004 is an 11β-hydroxysteroid dehydrogenase 1 inhibitor.
Nifurtimox
T5325
Nifurtimox is an antiprotozoal agent (IC50s = 9.91, 12.28, and 10.44 μM against Taluahuén, LQ, and Brener strains of T. cruzi­ epimastigotes, respectively).
3-Nitropropanoic acid
T3009
Bovinocidin is an irreversible inhibitor of succinate dehydrogenase.
4-Hydroxynonenal
T10148
4-Hydroxynonenal (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).
Physcion
T3019
Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenas...
Mycophenolate Mofetil
T6293
Mycophenolate mofetil, an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydroge...
XEN723
T13356
XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).
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