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Dehydrogenase

A dehydrogenase (also called DH or DHase in the literature) is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN. They also catalyze the reverse reaction, for instance alcohol dehydrogenase not only oxidizes ethanol to acetaldehyde in animals but also produces ethanol from acetaldehyde in yeast.
Cat. No. Product name CAS No. Purity Chemical Structure
T10160 11β-HSD1-IN-1 1203956-47-1 98%
11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1, IC50: 52 nM), and used for the treatment of pain.
T27214 DSM421 2011769-21-2 98%
DSM421 is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shown activity against ...
T60240 ALDH1A3-IN-2 886502-08-5 98%
ALDH1A3-IN-2 is a potent ALDH1A3 inhibitor with an IC50 of 0.30 μM.ALDH1A3-IN-2 has potential for cancer disease research.
T25209 CB29 315239-63-5 98%
CB29 is a specific inhibitor of aldehyde dehydrogenase 3A1 (ALDH3A1).
T67903 1-(biphenyl-4-ylsulfonyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine 946394-50-9 98%
1-(biphenyl-4-ylsulfonyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).
T67832 ALDH2 modulator 1 1629615-99-1 98%
ALDH2 modulator 1 is a potent and orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.
T25006 AGI-14100 1448346-43-7 98%
AGI-14100 is a novel and orally available mIDH1 inhibitor.AGI-14100 is used for the treatment of primary human myeloid leukemia.
T60364 DHODH-IN-17 16344-26-6 98%
DHODH-IN-17 is a human DHODH inhibitor with an IC50 of 0.40 μM. DHODH-IN-17 is a 2- anilino nicotinic acid that can be used in the study of acute myeloid leukemi...
T73143 PHGDH-IN-3 2893778-31-7 98%
PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH. PHGDH-IN-3 can be used in studies about can...
T3044 (E/Z)-Teriflunomide 108605-62-5 98%
Teriflunomide, a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.
T7732 Carbenoxolone 5697-56-3 98%
Carbenoxolone is an inhibitor of 11β-HSD and gap junction connexin channels. Carbenoxolone inhibits macrophage migration into atria and prevents the development ...
T2637 ADH-1 229971-81-7 98%
Exherin (ADH-1) is an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion with potential antineoplastic and antiangiogenic activities.
T64360 HDHODH-IN-8 2757405-31-3 98%
hDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 16 nM. hDHODH-IN-8 has potent antiproliferative activity and exc...
T14780 BRD9185 2057420-29-6 98%
BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.
T16269 Nanaomycin A 52934-83-5 98%
Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 5...
T11611 IDH1 Inhibitor 2 2244895-42-7 98%
IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).
T12663 (Rac)-BMS-816336 T12663 98%
(Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzym...
T11238 Etamicastat 760173-05-5 98%
Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor wit...
T14383 AZD8329 1048668-70-7 98%
AZD8329 is a selectable and potent inhibitor of human recombinant 11β-HSD1 and isolated human adipocyte 11ß-HSD1 and is an inhibitor of rat 11β-HSD1 (IC50 - 89nM...
T13054 T-3764518 1809151-56-1 98%
T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).
11β-HSD1-IN-1
T10160
11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1, IC50: 52 nM), and used for the treatment of pain.
DSM421
T27214
DSM421 is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shown activity against ...
ALDH1A3-IN-2
T60240
ALDH1A3-IN-2 is a potent ALDH1A3 inhibitor with an IC50 of 0.30 μM.ALDH1A3-IN-2 has potential for cancer disease research.
CB29
T25209
CB29 is a specific inhibitor of aldehyde dehydrogenase 3A1 (ALDH3A1).
1-(biphenyl-4-ylsulfonyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine
T67903
1-(biphenyl-4-ylsulfonyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).
ALDH2 modulator 1
T67832
ALDH2 modulator 1 is a potent and orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.
AGI-14100
T25006
AGI-14100 is a novel and orally available mIDH1 inhibitor.AGI-14100 is used for the treatment of primary human myeloid leukemia.
DHODH-IN-17
T60364
DHODH-IN-17 is a human DHODH inhibitor with an IC50 of 0.40 μM. DHODH-IN-17 is a 2- anilino nicotinic acid that can be used in the study of acute myeloid leukemi...
PHGDH-IN-3
T73143
PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH. PHGDH-IN-3 can be used in studies about can...
(E/Z)-Teriflunomide
T3044
Teriflunomide, a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.
Carbenoxolone
T7732
Carbenoxolone is an inhibitor of 11β-HSD and gap junction connexin channels. Carbenoxolone inhibits macrophage migration into atria and prevents the development ...
ADH-1
T2637
Exherin (ADH-1) is an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion with potential antineoplastic and antiangiogenic activities.
hDHODH-IN-8
T64360
hDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 16 nM. hDHODH-IN-8 has potent antiproliferative activity and exc...
BRD9185
T14780
BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.
Nanaomycin A
T16269
Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 5...
IDH1 Inhibitor 2
T11611
IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).
(Rac)-BMS-816336
T12663
(Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzym...
Etamicastat
T11238
Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor wit...
AZD8329
T14383
AZD8329 is a selectable and potent inhibitor of human recombinant 11β-HSD1 and isolated human adipocyte 11ß-HSD1 and is an inhibitor of rat 11β-HSD1 (IC50 - 89nM...
T-3764518
T13054
T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).
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