Cart
Metabolism Dehydrogenase

Dehydrogenase

A dehydrogenase (also called DH or DHase in the literature) is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN. They also catalyze the reverse reaction, for instance alcohol dehydrogenase not only oxidizes ethanol to acetaldehyde in animals but also produces ethanol from acetaldehyde in yeast.
Cat No. product name
T0010 Mercaptopurine Mercaptopurine is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metab...
T0036 Enoxolone Enoximone, a selective phosphodiesterase inhibitor, has vasodilating and positive inotropic activity. it does not cause changes of oxygen consumption in myocard...
T0054 Disulfiram Disulfiram is a carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the interm...
T0245 Mycophenolate mofetil Mycophenolate mofetil, an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydro...
T0256 Lithium citrate tribasic tetrahydrate Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and m...
T0361 Isovaleramide Isovaleramide is an anticonvulsant molecule isolated from Valeriana pavonii, which can inhibit the liver alcohol dehydrogenases.
T0414 D-Mannitol Mannitol is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any...
T0494 Tetramisole hydrochloride Tetramisole is used as an anthelmintic.
T0522 Diammonium Glycyrrhizinate Diammonium glycyrrhizinate, an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inh...
T0647 Tryptamine Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It...
T0684 Ribavirin Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
T0732 Benzyl alcohol Benzyl alcohol, a colorless liquid, is an aromatic alcohol with a mild pleasant aromatic odor.
T0746 Orotic acid Orotic acid is an intermediate product in pyrimidine metabolism.
T0897 Furacilin Nitrofurazone is a topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and s...
T0972 Isoniazid Isoniazid is an antibacterial agent used primarily as a tuberculostatic.
T1159 Leflunomide Leflunomide is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
T1165 Ethinamide Ethionamide is a nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unkn...
T1335 Mycophenolic acid Mycophenolic acid is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.
T1374 2-Picolinyl hydrazide 2-Picolinyl hydrazide is an effective inhibitor of Catalase-peroxidase-NAPDH.
T1473 Trilostane Trilostane is a synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenas...
T1485 Methotrexate Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties.
T1491 Atovaquone Atovaquone is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.
T1608 Exherin trifluoroacetate Exherin (ADH-1) is a cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitive...
T1717 Mangostin Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
T1809 AGI-6780 AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
T1869 NSC 14613 PluriSln 1(NSC 14613) is an inhibitor of stearoyl-CoA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism...
T1979 AVN944 AVN-944(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.
T2043 IDH1-IN-1 Mutant IDH1-IN-1 is a potent mutant IDH1 R132 h inhibitor with IC50 < 0.1 uM.
T2057 BVT 2733 BVT 2733 is a new, non-steroidal, isoform-specific inhibitor of 11β-HSD1.
T2104 AGI-5198 AGI-5198 is a highly effective and specific inhibitor of IDH1 R132H/R132C mutants (IC50: 0.07/0.16 μM).
T2121 SW033291 SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
T2346 Enasidenib Enasidenib is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineop...
T2447 AZD7545 AZD7545 is a potent PDHK inhibitor.
T2601 Vidofludimus Vidofludimus (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
T2650 MK-8245 MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.
T2662 Alda-1 Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrog...
T2741 Glycyrrhizin Glycyrrhizic acid is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.
T2901 Daidzin Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
T2970 Rotenone Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papilionoideae)...
T3044 Teriflunomide Teriflunomide, a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.
T3175 AZ-33 AZ-33 is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by SPR anal...
T3444 Merimepodib Merimepodib is a novel noncompetitive inhibitor of Inosine monophosphate dehydrogenase(IMPDH).
T3542 BVT-14225 BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor (IC50=52 nM).
T3617 Ivosidenib Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits ...
T4173 R162 R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor.
T4213 NCT-503 NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells.
T6157 CPI-613 CPI-613, a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial met...
T6384 Ammonium Glycyrrhizinate Ammonium Glycyrrhizinate inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.
T6518 Gossypol Gossypol Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
T4295 (R)-GNE-140 (R)-GNE-140 is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.
Mercaptopurine
T0010CAS 50-44-2
Mercaptopurine is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metab...
Enoxolone
T0036CAS 471-53-4
Enoximone, a selective phosphodiesterase inhibitor, has vasodilating and positive inotropic activity. it does not cause changes of oxygen consumption in myocard...
Disulfiram
T0054CAS 97-77-8
Disulfiram is a carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the interm...
Mycophenolate mofetil
T0245CAS 115007-34-6
Mycophenolate mofetil, an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydro...
Lithium citrate tribasic tetrahydrate
T0256CAS 6080-58-6
Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and m...
Isovaleramide
T0361CAS 541-46-8
Isovaleramide is an anticonvulsant molecule isolated from Valeriana pavonii, which can inhibit the liver alcohol dehydrogenases.
D-Mannitol
T0414CAS 69-65-8
Mannitol is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any...
Tetramisole hydrochloride
T0494CAS 5086-74-8
Tetramisole is used as an anthelmintic.
Diammonium Glycyrrhizinate
T0522CAS 79165-06-3
Diammonium glycyrrhizinate, an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inh...
Tryptamine
T0647CAS 61-54-1
Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It...
Ribavirin
T0684CAS 36791-04-5
Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
Benzyl alcohol
T0732CAS 100-51-6
Benzyl alcohol, a colorless liquid, is an aromatic alcohol with a mild pleasant aromatic odor.
Orotic acid
T0746CAS 65-86-1
Orotic acid is an intermediate product in pyrimidine metabolism.
Furacilin
T0897CAS 59-87-0
Nitrofurazone is a topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and s...
Isoniazid
T0972CAS 54-85-3
Isoniazid is an antibacterial agent used primarily as a tuberculostatic.
Leflunomide
T1159CAS 75706-12-6
Leflunomide is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
Ethinamide
T1165CAS 536-33-4
Ethionamide is a nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unkn...
Mycophenolic acid
T1335CAS 24280-93-1
Mycophenolic acid is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.
2-Picolinyl hydrazide
T1374CAS 1452-63-7
2-Picolinyl hydrazide is an effective inhibitor of Catalase-peroxidase-NAPDH.
Trilostane
T1473CAS 13647-35-3
Trilostane is a synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenas...
Methotrexate
T1485CAS 59-05-2
Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties.
Atovaquone
T1491CAS 95233-18-4
Atovaquone is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.
Exherin trifluoroacetate
T1608CAS 1135237-88-5
Exherin (ADH-1) is a cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitive...
Mangostin
T1717CAS 6147-11-1
Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
AGI-6780
T1809CAS 1432660-47-3
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
NSC 14613
T1869CAS 91396-88-2
PluriSln 1(NSC 14613) is an inhibitor of stearoyl-CoA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism...
AVN944
T1979CAS 297730-17-7
AVN-944(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.
IDH1-IN-1
T2043CAS 1355326-21-4
Mutant IDH1-IN-1 is a potent mutant IDH1 R132 h inhibitor with IC50 < 0.1 uM.
BVT 2733
T2057CAS 376640-41-4
BVT 2733 is a new, non-steroidal, isoform-specific inhibitor of 11β-HSD1.
AGI-5198
T2104CAS 1355326-35-0
AGI-5198 is a highly effective and specific inhibitor of IDH1 R132H/R132C mutants (IC50: 0.07/0.16 μM).
SW033291
T2121CAS 459147-39-8
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
Enasidenib
T2346CAS 1446502-11-9
Enasidenib is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineop...
AZD7545
T2447CAS 252017-04-2
AZD7545 is a potent PDHK inhibitor.
Vidofludimus
T2601CAS 717824-30-1
Vidofludimus (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
MK-8245
T2650CAS 1030612-90-8
MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.
Alda-1
T2662CAS 349438-38-6
Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrog...
Glycyrrhizin
T2741CAS 1405-86-3
Glycyrrhizic acid is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.
Daidzin
T2901CAS 552-66-9
Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
Rotenone
T2970CAS 83-79-4
Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papilionoideae)...
Teriflunomide
T3044CAS 108605-62-5
Teriflunomide, a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.
AZ-33
T3175CAS 1370290-34-8
AZ-33 is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by SPR anal...
Merimepodib
T3444CAS 198821-22-6
Merimepodib is a novel noncompetitive inhibitor of Inosine monophosphate dehydrogenase(IMPDH).
BVT-14225
T3542CAS 376638-65-2
BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor (IC50=52 nM).
Ivosidenib
T3617CAS 1448347-49-6
Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits ...
R162
T4173CAS 64302-87-0
R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor.
NCT-503
T4213CAS 1916571-90-8
NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells.
CPI-613
T6157CAS 95809-78-2
CPI-613, a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial met...
Ammonium Glycyrrhizinate
T6384CAS 1407-03-0
Ammonium Glycyrrhizinate inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.
Gossypol
T6518CAS 303-45-7
Gossypol Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
(R)-GNE-140
T4295CAS 2003234-63-5
(R)-GNE-140 is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.