T10733 |
CDDO-EA |
CDDO-EA is an activator of NF-E2 related factor 2/antioxidant response element (Nrf2/ARE). |
T11251 |
Ezetimibe ketone |
Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor.Ezetimibe ketone...
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T12253 |
Nrf2-IN-1 |
Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML). |
T13467 |
(±)-BAY-1251152 |
(±)-BAY-1251152 is a racemic mixture of BAY-1251152. BAY-1251152 is highly selective inhibitor of PTEF/CDK9. |
T15474 |
Hesperin |
Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi). It has been shown to be an activator of Nrf2. |
T1593 |
Ezetimibe |
Ezetimibe is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption. |
T16352 |
NSC23925 |
NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp). |
T2915 |
Bardoxolone |
CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse ma...
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T2A2486 |
5,7,3',4',5'-Pentamethoxyflavone |
3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adj...
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T3012 |
Mangiferin |
Mangiferin is used for antidiabetes. Extracted from Mangifera indica L. |
T4360 |
ML385 |
ML385 is a new-type and selective NRF2 inhibitor. |
T5364 |
TBHQ |
Tert-butylhydroquinone (tBHQ) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2. |
T5S1805 |
5,7-Dihydroxychromone |
1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5, 7-Dihydroxychromone exert...
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T6919 |
Omaveloxolone |
Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2. |
T8704 |
4-hydroxyphenyl acetate |
4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer |
T9112 |
(-)-Perillaldehyde |
(-)-Perillaldehyde shows antibacterial activity. |
TMA0237 |
Carlinoside |
Carlinoside could be a worthy choice to intervene hyperbilirubinemia due to liver dysfunction. Carlinoside upregulates Nrf2 gene expression, increases its nucle...
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TMA1570 |
Sappanone A |
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2...
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TN1058 |
Pelargonidin chloride |
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels ...
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TN1151 |
Procyanidin B4 |
Procyanidin B4 reveals significant antioxidant activity |
TN1461 |
Butin |
Butin has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates ox...
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TN1548 |
Daidzin 6''-O-malonate |
Daidzin 6''-O-malonate may have anticancer activity. |
TN1621 |
Eriodictyol-7-O-glucoside |
Eriodictyol-7-O-glucoside and epicatechin appears to be responsible for the antioxidant activity of pistachio skin. |
TN1670 |
Ganodermanondiol |
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated ant...
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TN1989 |
Niga-ichigoside F1 |
Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects. |
TN2166 |
Rupestonic acid |
Rupestonic acid derivatives have an anti-influenza virus activity, they inhibit IAV by up-regulating HO-1-mediated IFN response. |
TN2272 |
Tigloylgomisin H |
Tigloylgomisin H represents a potential liver cancer prevention agent, it can significantly induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarc...
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TN3694 |
Coniferaldehyde |
Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 de...
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TN3726 |
Cudraflavone B |
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and m...
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TN3806 |
Dehydroglyasperin C |
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemo...
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TN4038 |
Eupatolide |
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
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TN4064 |
Flavoglaucin |
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or canna...
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TN4160 |
Goniothalamin |
Goniothalamin is a natural product that has been demonstrated to induce apoptosis in various cancer cell lines, can induce cytotoxicity and apoptosis on RT4 cel...
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TN4234 |
Hydrangenol |
Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PC...
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TN4420 |
Latifolin |
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Lati...
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TN4583 |
Moringin |
Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of expe...
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TN5278 |
Zederone |
Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads ...
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TN6711 |
toralactone |
Toralactone is a natural product isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism |
TN6711 |
toralactone |
Toralactone is a natural product isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism |
TQ0120 |
CDDO-Im |
CDDO-Im is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ). |
TQ0199 |
Ginsenoside Rh3 |
Ginsenoside Rh3 is a natural product extracted from Panax ginseng C. A. Mey. Ginsenoside Rh3 treatment in human retinal cells induces Nrf2 activation. |
TQ0211 |
Brusatol |
Brusatol is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2. |