Nrf2

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.

Cat No.	product name
T1593	Ezetimibe	Ezetimibe is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.
T2915	Bardoxolone	CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse ma...
T6919	Omaveloxolone	Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
T4360	ML385	ML385 is a new-type and selective NRF2 inhibitor.
T5S1805	5,7-Dihydroxychromone	1. 5,7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exe...
T5364	TBHQ	Tert-butylhydroquinone (tBHQ) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.
TQ0199	Ginsenoside Rh3	Ginsenoside Rh3 is a natural product extracted from Panax ginseng C. A. Mey. Ginsenoside Rh3 treatment in human retinal cells induces Nrf2 activation.
TQ0211	Brusatol	Brusatol is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.
TQ0120	CDDO-Im	CDDO-Im is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
TN1151	Procyanidin B4	Procyanidin B4 reveals significant antioxidant activity
TN1621	Eriodictyol-7-O-glucoside	Eriodictyol-7-O-glucoside and epicatechin appears to be responsible for the antioxidant activity of pistachio skin.
TN1670	Ganodermanondiol	Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated ant...
TN1989	Niga-ichigoside F1	Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects.
TN2166	Rupestonic acid	Rupestonic acid derivatives have an anti-influenza virus activity, they inhibit IAV by up-regulating HO-1-mediated IFN response.
TN2272	Tigloylgomisin H	Tigloylgomisin H represents a potential liver cancer prevention agent, it can significantly induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarc...
TN1548	Daidzin 6''-O-malonate	Daidzin 6''-O-malonate may have anticancer activity.
TN1058	Pelargonidin chloride	Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels ...
TN1461	Butin	Butin has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates ox...
T12253	Nrf2-IN-1	Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor.
T11251	Ezetimibe ketone	Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor.Ezetimibe ketone...
T10733	CDDO-EA	CDDO-EA is an activator of NF-E2 related factor 2/antioxidant response element (Nrf2/ARE).
T15474	Hesperin	Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi). It has been shown to be an activator of Nrf2.
T13467	(±)-BAY-1251152	(±)-BAY-1251152 is a racemic mixture of BAY-1251152. BAY-1251152 is highly selective inhibitor of PTEF/CDK9.
T16352	NSC23925	NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).
T2A2486	5,7,3',4',5'-Pentamethoxyflavone	3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adj...
TMA0237	Carlinoside	Carlinoside could be a worthy choice to intervene hyperbilirubinemia due to liver dysfunction. Carlinoside upregulates Nrf2 gene expression, increases its nucle...
TN3694	Coniferaldehyde	Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 de...
TN3726	Cudraflavone B	Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and m...
TN3806	Dehydroglyasperin C	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemo...
TN4038	Eupatolide	Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
TN4064	Flavoglaucin	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or canna...
TN4160	Goniothalamin	Goniothalamin is a natural product that has been demonstrated to induce apoptosis in various cancer cell lines, can induce cytotoxicity and apoptosis on RT4 cel...
TN4234	Hydrangenol	Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PC...
TN4420	Latifolin	Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-ÎºB activation via Nrf2-mediated heme oxygenase-1 expression. Lati...
TN4583	Moringin	Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of expe...
TMA1570	Sappanone A	Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2...
TN5278	Zederone	Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads ...
T8704	4-hydroxyphenyl acetate	4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer