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KI696

Catalog No. T11758LCas No. 1799974-70-1

KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.

KI696

KI696

Purity: 98.42%
Catalog No. T11758LCas No. 1799974-70-1
KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.
Pack SizePriceAvailabilityQuantity
1 mg$147In Stock
5 mg$369In Stock
10 mg$588In Stock
25 mg$1,080In Stock
50 mg$1,480In Stock
100 mg$1,970In Stock
1 mL x 10 mM (in DMSO)$472In Stock
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Purity:98.42%
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Product Introduction

Bioactivity
Description
KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.
In vitro
KI696 displays high affinity for the KEAP1 Kelch domain with ITC Kd of 1.3 nM with the exception of the organic anion transporting polypeptide 1B1, the bile salt export pump BSEP and the phosphodiesterase PDE3A with an IC50 of 2.5 µM, 4.0 µM and 10 µM). KI696 causes an increase of NRF2 Nuclear Translocation in Normal Human Bronchial Epithelial cells and mRNA expression of the NRF2-dependent genes NQO1 and GCLM in NHBE cells transfected with the non-targeting siRNA in an NRF2-dependent manner[1].
In vivo
KI696 induces the expression of the Nqo1, Ho-1, Txnrd1, Srxn1, Gsta3, and Gclc genes in a dose-dependent manner with EC50s of 44.0, 25.7, 42.6, 33.8, 28.4, and 44.1 µmol/kg, respectively. KI696 attenuates ozone-Induced pulmonary inflammation and restores depletion of lung GSH levels. In rats, intravenous administration of KI696(10-50 µmol/kg) results in steady state compound concentrations in the blood of 407-1437 nM[1].
Chemical Properties
Molecular Weight550.63
FormulaC28H30N4O6S
Cas No.1799974-70-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45.0 mg/mL (81.7 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8161 mL9.0805 mL18.1610 mL90.8051 mL
5 mM0.3632 mL1.8161 mL3.6322 mL18.1610 mL
10 mM0.1816 mL0.9081 mL1.8161 mL9.0805 mL
20 mM0.0908 mL0.4540 mL0.9081 mL4.5403 mL
50 mM0.0363 mL0.1816 mL0.3632 mL1.8161 mL

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