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Tigloylgomisin H

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COA HNMR HPLC

Tigloylgomisin H

Catalog No. TN2272Cas No. 66069-55-4

Tigloylgomisin H significantly induces quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway and can be used in liver cancer prevention studies.

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Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$118	In Stock
10 mg	$198	In Stock
25 mg	$339	In Stock
50 mg	$474	In Stock
100 mg	$654	In Stock
1 mL x 10 mM (in DMSO)	$160	In Stock

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Product Introduction

Bioactivity

Description

Tigloylgomisin H represents a potential liver cancer prevention agent, it can significantly induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells, it functions as a novel monofunctional inducer that specifically upregulates phase

In vitro

In the current study, nine lignans were isolated from S. chinensis and tested for their ability to induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H (TGH) and angeloylgomisin H (AGH) significantly induced QR activity and exhibited a relatively high chemoprevention index (CI) (10.80 and 4.59, respectively) as compared to control. TGH also induced QR activity in BPrc1 mouse hepatocarcinoma cells as well, which are defective in aryl hydrocarbon nuclear translocator (Arnt). In HepG2 human hepatocarcinoma cells, TGH significantly activated gene expression mediated by the antioxidant response element (ARE), a key regulatory region in the promoters of detoxification enzymes, through the nuclear accumulation of Nrf2.

Chemical Properties

Molecular Weight	500.58
Formula	C28H36O8
Cas No.	66069-55-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (99.88 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9977 mL	9.9884 mL	19.9768 mL	99.8841 mL
5 mM	0.3995 mL	1.9977 mL	3.9954 mL	19.9768 mL
10 mM	0.1998 mL	0.9988 mL	1.9977 mL	9.9884 mL
20 mM	0.0999 mL	0.4994 mL	0.9988 mL	4.9942 mL
50 mM	0.0400 mL	0.1998 mL	0.3995 mL	1.9977 mL

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