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3',​4',​5',​5,​7-​Pentamethoxyflavone

🥰Excellent
Catalog No. T2A2486Cas No. 53350-26-8
Alias 5,7,3',4',5'-Pentamethoxyflavone

3',4',5',5,7-Pentamethoxyflavone is a naturally occurring brassinosteroid compound from the Rutaceae family that exhibits cancer cell resistance by inhibiting the Nrf2 pathway to overcome chemotherapeutically active molecules.

3',​4',​5',​5,​7-​Pentamethoxyflavone

3',​4',​5',​5,​7-​Pentamethoxyflavone

🥰Excellent
Purity: 98%
Catalog No. T2A2486Alias 5,7,3',4',5'-PentamethoxyflavoneCas No. 53350-26-8
3',4',5',5,7-Pentamethoxyflavone is a naturally occurring brassinosteroid compound from the Rutaceae family that exhibits cancer cell resistance by inhibiting the Nrf2 pathway to overcome chemotherapeutically active molecules.
Pack SizePriceAvailabilityQuantity
1 mg$42In Stock
5 mg$103In Stock
10 mg$178In Stock
25 mg$295In Stock
50 mg$431In Stock
1 mL x 10 mM (in DMSO)$116In Stock
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Purity:98%
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Product Introduction

Bioactivity
Description
3',4',5',5,7-Pentamethoxyflavone is a naturally occurring brassinosteroid compound from the Rutaceae family that exhibits cancer cell resistance by inhibiting the Nrf2 pathway to overcome chemotherapeutically active molecules.
In vitro
3',4',5',5,7-Pentamethoxyflavone (PMF), a natural flavonoid extracted from Rutaceae plants, sensitized A549/CDDP to CDDP and substantially induced apoptosis compared with that of CDDP alone treated group, and this reversal effect decreased when Nrf2 was downregulated by siRNA. Mechanistically, PMF reduced Nrf2 expression leading to a reduction of Nrf2 downstream genes, and in contrast, this effect was decreased by blocking Nrf2 with siRNA. Taken together, these results demonstrated that PMF could be used as an effective adjuvant sensitizer to increase the efficacy of chemotherapeutic drugs by downregulating Nrf2 signaling pathway.[1]
In vivo
The flavones tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone) and 3',4',5',5,7-Pentamethoxyflavone (PMF) are under development as potential colorectal cancer chemopreventive agents as they reduced adenoma development in the Apc(Min) mouse model of intestinal carcinogenesis. Plasma concentrations and area under the plasma concentration versus time curve for PMF were higher than those for tricin. A mono-O-desmethyl PMF and several isomeric mono-O-desmethyl PMF glucuronides and sulfonates were major PMF metabolites in murine plasma, liver and intestinal tissue. In murine and human liver fractions, in vitro metabolic removal of tricin was faster than that of PMF[1].
Alias5,7,3',4',5'-Pentamethoxyflavone
Chemical Properties
Molecular Weight372.37
FormulaC20H20O7
Cas No.53350-26-8
SmilesCOc1cc(OC)c2c(c1)oc(cc2=O)-c1cc(OC)c(OC)c(OC)c1
Relative Density.1.244g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 22.5 mg/mL (60.4 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6855 mL13.4275 mL26.8550 mL134.2750 mL
5 mM0.5371 mL2.6855 mL5.3710 mL26.8550 mL
10 mM0.2686 mL1.3428 mL2.6855 mL13.4275 mL
20 mM0.1343 mL0.6714 mL1.3428 mL6.7138 mL
50 mM0.0537 mL0.2686 mL0.5371 mL2.6855 mL

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