Shopping Cart
- Remove All
Your shopping cart is currently empty
3',4',5',5,7-Pentamethoxyflavone
🥰Excellent
Catalog No. T2A2486Cas No. 53350-26-8
Alias 5,7,3',4',5'-Pentamethoxyflavone
3',4',5',5,7-Pentamethoxyflavone is a naturally occurring brassinosteroid compound from the Rutaceae family that exhibits cancer cell resistance by inhibiting the Nrf2 pathway to overcome chemotherapeutically active molecules.
3',4',5',5,7-Pentamethoxyflavone
🥰Excellent
Purity: 98%
Catalog No. T2A2486Alias 5,7,3',4',5'-PentamethoxyflavoneCas No. 53350-26-8
3',4',5',5,7-Pentamethoxyflavone is a naturally occurring brassinosteroid compound from the Rutaceae family that exhibits cancer cell resistance by inhibiting the Nrf2 pathway to overcome chemotherapeutically active molecules.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $42 | In Stock | |
| 5 mg | $103 | In Stock | |
| 10 mg | $178 | In Stock | |
| 25 mg | $295 | In Stock | |
| 50 mg | $431 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $116 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "3',4',5',5,7-Pentamethoxyflavone"
Curcumin
Cited
Turmeric yellow, Natural Yellow 3, Indian Saffron, Diferuloylmethane
T1516458-37-7
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, anti-inflammatory and antioxidant.
AutophagyEpigenetic Reader DomainFerroptosisHDACHistone AcetyltransferaseInfluenza VirusMitophagyNrf2
- $30
Size
QTY
CitedDimethyl fumarate Cited
DMF
T0492624-49-7
Dimethyl fumarate (DMF) is an Nrf2 activator with oral activity and blood-brain barrier permeability. Dimethyl fumarate has antimicrobial, anti-inflammatory, and immunomodulatory activities and has been used in the study of multiple sclerosis.
- $45
Size
QTY
CitedTBHQ
Cited
tert-Butylhydroquinone
T53641948-33-0
TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.
- $41
Size
QTY
CitedResveratrol Cited
trans-Resveratrol, SRT 501
T1558501-36-0
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.
AntibacterialAntibioticAntifungalApoptosisAutophagyCOXDNA/RNA SynthesisIκB/IKKLipoxygenaseMitophagyNADPHNrf2Sirtuin
- $36
Size
QTY
CitedMethyl 3,4-dihydroxybenzoate
Protocatechuic acid methyl ester, Methyl protocatechuate, 3,4-Dihydroxybenzoic acid methyl ester
T13682150-43-8
Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester), a key metabolite of antioxidant polyphenols in green tea, exhibits significant antioxidant and anti-inflammatory properties.
- $42
Size
QTY
L-Cystine dihydrochloride
T6078930925-07-6
L-Cystine dihydrochloride is an Nrf2 inducer with whitening and anti-dark spot effects.L-Cystine dihydrochloride has cytoprotective effects in cells, and is often added to various fungal cultures as a carbon source.
- $40
Size
QTY
Pyridoxine hydrochloride
Vitamin B6 (hydrochloride), Vitamin B6, Pyridoxol (hydrochloride), Pyridoxine HCl
T0973L58-56-0
Pyridoxine hydrochloride (Vitamin B6) is the 4-methanol form of vitaminB6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid.
- $30
Size
QTY
Ezetimibe Cited
SCH 58235
T1593163222-33-1
Ezetimibe (SCH 58235) is a dietary cholesterol absorption inhibitor that exerts its physiologic effect by decreasing cholesterol absorption.
- $41
Size
QTY
CitedLuteolin Cited
Luteolol, Luteoline, Flacitran, Digitoflavone
T1027491-70-3
Luteolin (Luteolol) belongs to the flavonoid group of natural products and is a Nrf2 inhibitor, PDE inhibitor. Luteolin has a wide range of biological activities including antitumor, antioxidant, anti-inflammatory, antimicrobial, antiviral, antiallergic, and procoagulant.
- $39
Size
QTY
CitedOltipraz
RP 35972, NSC 347901
T015364224-21-1
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quinone oxidoreductase 1 (NQO1). The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.
- $31
Size
QTY
Mangiferin Cited
Hedysarid, Chinomin, Alpizarin
T30124773-96-0
Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.
- $38
Size
QTY
CitedPyridoxine Cited
Vitamin B6, Pyridoxol, Gravidox
T097365-23-6
Pyridoxine (Vitamin B6) is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Although pyridoxine and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading.
- $39
Size
QTY
CitedSelect Batch
Purity:98%
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | 3',4',5',5,7-Pentamethoxyflavone is a naturally occurring brassinosteroid compound from the Rutaceae family that exhibits cancer cell resistance by inhibiting the Nrf2 pathway to overcome chemotherapeutically active molecules. |
| In vitro | 3',4',5',5,7-Pentamethoxyflavone (PMF), a natural flavonoid extracted from Rutaceae plants, sensitized A549/CDDP to CDDP and substantially induced apoptosis compared with that of CDDP alone treated group, and this reversal effect decreased when Nrf2 was downregulated by siRNA. Mechanistically, PMF reduced Nrf2 expression leading to a reduction of Nrf2 downstream genes, and in contrast, this effect was decreased by blocking Nrf2 with siRNA. Taken together, these results demonstrated that PMF could be used as an effective adjuvant sensitizer to increase the efficacy of chemotherapeutic drugs by downregulating Nrf2 signaling pathway.[1] |
| In vivo | The flavones tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone) and 3',4',5',5,7-Pentamethoxyflavone (PMF) are under development as potential colorectal cancer chemopreventive agents as they reduced adenoma development in the Apc(Min) mouse model of intestinal carcinogenesis. Plasma concentrations and area under the plasma concentration versus time curve for PMF were higher than those for tricin. A mono-O-desmethyl PMF and several isomeric mono-O-desmethyl PMF glucuronides and sulfonates were major PMF metabolites in murine plasma, liver and intestinal tissue. In murine and human liver fractions, in vitro metabolic removal of tricin was faster than that of PMF[1]. |
| Alias | 5,7,3',4',5'-Pentamethoxyflavone |
| Molecular Weight | 372.37 |
| Formula | C20H20O7 |
| Cas No. | 53350-26-8 |
| Smiles | COc1cc(OC)c2c(c1)oc(cc2=O)-c1cc(OC)c(OC)c(OC)c1 |
| Relative Density. | 1.244g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 22.5 mg/mL (60.4 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy 3',4',5',5,7-Pentamethoxyflavone | purchase 3',4',5',5,7-Pentamethoxyflavone | 3',4',5',5,7-Pentamethoxyflavone cost | order 3',4',5',5,7-Pentamethoxyflavone | 3',4',5',5,7-Pentamethoxyflavone chemical structure | 3',4',5',5,7-Pentamethoxyflavone in vivo | 3',4',5',5,7-Pentamethoxyflavone in vitro | 3',4',5',5,7-Pentamethoxyflavone formula | 3',4',5',5,7-Pentamethoxyflavone molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.