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AEM1

🥰Excellent
Catalog No. T8979Cas No. 1030123-90-0

AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer. AEM1 acts by broadly decreasing the expression of NRF2 controlled genes, sensitizing A549 cells to various chemotherapeutic agents, and inhibiting the growth of A549 cells in vitro and in vivo.

AEM1

AEM1

🥰Excellent
Purity: 97.87%
Catalog No. T8979Cas No. 1030123-90-0
AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer. AEM1 acts by broadly decreasing the expression of NRF2 controlled genes, sensitizing A549 cells to various chemotherapeutic agents, and inhibiting the growth of A549 cells in vitro and in vivo.
Pack SizePriceAvailabilityQuantity
5 mg$47In Stock
10 mg$84In Stock
25 mg$178In Stock
50 mg$313In Stock
100 mg$537In Stock
1 mL x 10 mM (in DMSO)$81In Stock
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Purity:97.87%
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Product Introduction

Bioactivity
Description
AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer. AEM1 acts by broadly decreasing the expression of NRF2 controlled genes, sensitizing A549 cells to various chemotherapeutic agents, and inhibiting the growth of A549 cells in vitro and in vivo.
Chemical Properties
Molecular Weight379.41
FormulaC20H14FN3O2S
Cas No.1030123-90-0
SmilesFC1=CC=C(C=C1)C1=CSC2=C1C(NCC1=CC=C3OCOC3=C1)=NC=N2
Relative Density.1.457 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (79.07 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6357 mL13.1784 mL26.3567 mL131.7836 mL
5 mM0.5271 mL2.6357 mL5.2713 mL26.3567 mL
10 mM0.2636 mL1.3178 mL2.6357 mL13.1784 mL
20 mM0.1318 mL0.6589 mL1.3178 mL6.5892 mL
50 mM0.0527 mL0.2636 mL0.5271 mL2.6357 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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