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TAT 14

TAT 14
TAT 14, a 14-mer peptide, is an Nrf2 activator with anti-inflammatory properties. TAT-14 increases Nrf2 protein levels due to targeting the Nrf2 binding site on Keap1, but has no effect on Nrf2 mRNA expression.
Catalog No. TP2109Cas No. 1362661-34-4

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TAT 14

Catalog No. TP2109Cas No. 1362661-34-4

TAT 14, a 14-mer peptide, is an Nrf2 activator with anti-inflammatory properties. TAT-14 increases Nrf2 protein levels due to targeting the Nrf2 binding site on Keap1, but has no effect on Nrf2 mRNA expression.
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Pack SizePriceAvailabilityQuantity
1 mg$148Backorder
5 mg$456Backorder
10 mg$728Backorder
25 mg$1,250Backorder
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Product Introduction

Bioactivity
Description
Nrf2 activator; inhibits Nrf2/Keap1 interaction. Induces upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1. Suppresses LPS-induced TNF-α expression in THP-1 cells.
Chemical Properties
Molecular Weight3173.59
FormulaC137H230N48O39
Cas No.1362661-34-4
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 100 mg/mL (31.51 mM)
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.3151 mL1.5755 mL3.1510 mL15.7550 mL
5 mM0.0630 mL0.3151 mL0.6302 mL3.1510 mL
10 mM0.0315 mL0.1576 mL0.3151 mL1.5755 mL
20 mM0.0158 mL0.0788 mL0.1576 mL0.7878 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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