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I-152
Catalog No. T75128Cas No. 311343-11-0
Alias I152
I-152 is a coupling of N-acetylcysteine and β-mercaptoethylamine. I-152 has antiproliferative, antiviral, and immunomodulatory activities. I-152 is used in the study of viral infections because it activates NRF2 and ATF4 signaling.
I-152
Catalog No. T75128Alias I152Cas No. 311343-11-0
I-152 is a coupling of N-acetylcysteine and β-mercaptoethylamine. I-152 has antiproliferative, antiviral, and immunomodulatory activities. I-152 is used in the study of viral infections because it activates NRF2 and ATF4 signaling.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $78 | In Stock | |
| 5 mg | $210 | 7-10 days | |
| 10 mg | $360 | 7-10 days | |
| 25 mg | $619 | 7-10 days | |
| 50 mg | $993 | 7-10 days | |
| 100 mg | $1,590 | 7-10 days |
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Purity:98.36%
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Product Introduction
Bioactivity
Chemical Properties
| Description | I-152 is a coupling of N-acetylcysteine and β-mercaptoethylamine. I-152 has antiproliferative, antiviral, and immunomodulatory activities. I-152 is used in the study of viral infections because it activates NRF2 and ATF4 signaling. |
| In vitro | When I-152 is treated with RAW 264.7 cells at a concentration of 1 mM, it decreases the level of NRF2 mRNA after 1 h or 2 h; treatment for 0-60 min not only decreases the levels of NRF2 and p53, but also increases the expression of ATF4. In addition, at concentrations of 0.062, 0.125, 0.25, or 1 mM, I-152 was able to increase the levels of Gclc mRNA and Chac1 mRNA after 6 h or 24 h, and increase Chop mRNA expression after 6 h. The expression of Chac1 mRNA was also increased at concentrations of 0.062, 0.125, 0.25, or 1 mM. I-152 also increased GSH levels in RAW 264.7 cells when treated at concentrations of 0.062, 0.125, 0.25, or 1 mM for 2 hours. At a concentration of 1 mM, I-152 treatment for 1 h, 2 h, 6 h and 24 h activated the expression of ATF4 mRNA in RAW 264.7 cells; whereas treatment for 24 h and 48 h produced cytotoxicity and inhibited the growth of RAW 264.7 cells. [1] |
| Alias | I152 |
| Molecular Weight | 264.37 |
| Formula | C9H16N2O3S2 |
| Cas No. | 311343-11-0 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (302.61 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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