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CDDO-EA
Catalog No. T10733Cas No. 932730-51-3
Alias TP319, RTA 405, CDDO ethyl amide
CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.
CDDO-EA
Catalog No. T10733Alias TP319, RTA 405, CDDO ethyl amideCas No. 932730-51-3
CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $97 | In Stock | |
| 5 mg | $213 | In Stock | |
| 10 mg | $389 | In Stock | |
| 25 mg | $655 | In Stock | |
| 50 mg | $932 | In Stock | |
| 100 mg | $1,270 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $243 | In Stock |
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Purity:98.54%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element. |
| In vitro | In a cell culture model of ALS, CDDO-EA potently activates Nrf2/ARE [1]. CDDO-EA induces apoptosis in A549 lung cancer cells and induces heme oxygenase-1. CDDO-EA is 7-fold more potent than CDDO as a suppressor of the ability of IFN-γ to induce iNOS in RAW264.7 macrophage-like cells[2]. |
| In vivo | CDDO-EA-treated G93A mice live significantly longer than the control. CDDO-EA increases the life-span from 124.05 days to 144.72 days (16.6%). In CDDO-EA-treated G93A mice, the age of death is 141.4 days and the duration from the age of onset to the age of death is 57.6 days. The age of death from the onset is prolonged by 17.5 days (43%) [1]. |
| Alias | TP319, RTA 405, CDDO ethyl amide |
| Molecular Weight | 518.73 |
| Formula | C33H46N2O3 |
| Cas No. | 932730-51-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (57.8 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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