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Netarsudil Dihydrochloride

Catalog No. T10358 CAS 1253952-02-1

Synonyms: AR-13324 Dihydrochloride

Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Netarsudil Dihydrochloride Chemical Structure

Netarsudil Dihydrochloride, CAS 1253952-02-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 96.00
2 mg	In stock	$ 142.00
5 mg	In stock	$ 250.00
10 mg	In stock	$ 443.00
25 mg	In stock	$ 732.00
50 mg	In stock	$ 987.00
100 mg	In stock	$ 1,390.00

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Purity: 99.98%

Purity: 99.94%

Biological Description

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Storage & Solubility Information

Description	Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction.
In vivo	Netarsudil Dihydrochloride (AR-13324 Dihydrochloride; 0.04%, 50 ΜL)reduces intraocular pressure (IOP) in normotensive monkey eyes [1]. Netarsudil Dihydrochloride (0.04%) produces a statistically significant lowering of episcleral venous pressure (EVP) in Dutch Belted rabbits [2].

Synonyms	AR-13324 Dihydrochloride
Molecular Weight	526.45
Formula	C28H29Cl2N3O3
CAS No.	1253952-02-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (94.98 mM), Sonication is recommended.

References and Literature

1. Wang RF, et al. Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24(1):51-54. 2. Kiel JW, et al. Effect of AR-13324 on episcleral venous pressure in Dutch belted rabbits. J Ocul Pharmacol Ther. 2015 Apr;31(3):146-151.

Related compound libraries

This product is contained In the following compound libraries：

TGF-beta/Smad Compound Library Inhibitor Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library EMA Approved Drug Library Anti-Cancer Drug Library Kinase Inhibitor Library FDA-Approved Kinase Inhibitor Library Stem Cell Differentiation Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets

ROCK2-IN-6 hydrochloride WAY-656935 GSK269962A SAR407899 GSK180736A CKI-7 Hydroxyfasudil Cotosudil

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Netarsudil Dihydrochloride 1253952-02-1 Cell Cycle/Checkpoint Cytoskeletal Signaling Stem Cells ROCK AR-13324 Dihydrochloride AR13324 Dihydrochloride AR 13324 Netarsudil AR 13324 Dihydrochloride AR-13324 AR13324 inhibitor inhibit

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