T23888 |
CID-5056270
|
681173-76-2
|
98%
|
|
CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma, ...
|
T11402L |
GKI-1 HCl
|
T11402L
|
98%
|
|
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.
|
T10888 |
CRT0066854 hydrochloride
|
2250019-91-9
|
98%
|
|
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 valu...
|
T7492 |
Ripasudil free base
|
223645-67-8
|
98%
|
|
Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
|
T13364 |
YAP/TAZ inhibitor-1
|
2093565-23-0
|
98%
|
|
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
|
T13972 |
Y-9738
|
59399-41-6
|
98%
|
|
Y-9738 is an agent of hypolipidemic.
|
T16855 |
SB-772077B dihydrochloride
|
607373-46-6
|
98%
|
|
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
|
TN1533 |
Cucurbitacin A
|
6040-19-3
|
98%
|
|
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
|
T15808 |
Merestinib dihydrochloride
|
1206801-37-7
|
98%
|
|
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
|
T15798 |
LX7101
|
1192189-69-7
|
98%
|
|
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
|
T7552 |
H-1152
|
451462-58-1
|
98%
|
|
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
|
TQ0187 |
SR-3677
|
1072959-67-1
|
98%
|
|
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
|
T7391 |
SAR407899
|
923359-38-0
|
98%
|
|
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
|
T12746 |
ROCK inhibitor-2
|
1127308-52-4
|
98%
|
|
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
|
T1870 |
Y-27632
|
146986-50-7
|
98%
|
|
Y-27632 is a selective ATP-competitive inhibitor of ROCK-I and ROCK-II.
|
T4276 |
Hydroxyfasudil Hydrochloride
|
155558-32-0
|
98%
|
|
Hydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
|
T4095 |
ZINC00881524
|
557782-81-7
|
98%
|
|
ZINC00881524 is an effective and specific ROCK inhibitor.
|
T1911 |
Afuresertib
|
1047644-62-1
|
98%
|
|
Afuresertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
|
T1898 |
RKI-1447
|
1342278-01-6
|
98%
|
|
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
|
TQ0183 |
Narciclasine
|
29477-83-6
|
98%
|
|
Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
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