T7492 |
Ripasudil free base
|
223645-67-8
|
98%
|
|
Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
|
T23308 |
SAR407899 hydrochloride
|
923262-96-8
|
98%
|
|
ATP-competitive ROCK inhibitor
|
T13364 |
YAP/TAZ inhibitor-1
|
2093565-23-0
|
98%
|
|
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
|
T13972 |
Y-9738
|
59399-41-6
|
98%
|
|
Y-9738 is an agent of hypolipidemic.
|
T15808 |
Merestinib dihydrochloride
|
1206801-37-7
|
98%
|
|
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
|
TN1533 |
Cucurbitacin A
|
6040-19-3
|
98%
|
|
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
|
T16855 |
SB-772077B dihydrochloride
|
607373-46-6
|
98%
|
|
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
|
T7552 |
H-1152
|
451462-58-1
|
98%
|
|
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
|
T35328 |
H-1152 dihydrochloride
|
871543-07-6
|
98%
|
|
|
T1606 |
Fasudil
|
103745-39-7
|
98%
|
|
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
|
T9652 |
SB-747651A Dihydrochloride
|
1781882-72-1
|
98%
|
|
SB-747651A Dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A Dihydrochloride also i...
|
T12747 |
ROCK2-IN-2
|
1995065-79-6
|
98%
|
|
ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
|
TQ0183 |
Narciclasine
|
29477-83-6
|
98%
|
|
Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
|
T7885 |
Afuresertib hydrochloride
|
1047645-82-8
|
100%
|
|
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
|
T19913 |
CKI-7
|
1177141-67-1
|
100.00%
|
|
CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
|
TQ0110 |
ROCK-IN-2
|
867017-68-3
|
97.59%
|
|
Azaindole 1 is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
|
T7301 |
BDP5290
|
1817698-21-7
|
98%
|
|
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
|
T2482 |
AT13148
|
1056901-62-2
|
98.04%
|
|
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
|
T2633 |
GSK429286A
|
864082-47-3
|
98.42%
|
|
GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
|
T3513 |
GSK180736A
|
817194-38-0
|
98.44%
|
|
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), b...
|