Home Tools
Log in
Cart

ROCK

Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.
Cat. No. Product name CAS No. Purity Chemical Structure
T23888 CID-5056270 681173-76-2 98%
CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma, ...
T11402L GKI-1 HCl T11402L 98%
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.
T10888 CRT0066854 hydrochloride 2250019-91-9 98%
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 valu...
T7492 Ripasudil free base 223645-67-8 98%
Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
T13364 YAP/TAZ inhibitor-1 2093565-23-0 98%
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
T13972 Y-9738 59399-41-6 98%
Y-9738 is an agent of hypolipidemic.
T16855 SB-772077B dihydrochloride 607373-46-6 98%
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
TN1533 Cucurbitacin A 6040-19-3 98%
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
T15808 Merestinib dihydrochloride 1206801-37-7 98%
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
T15798 LX7101 1192189-69-7 98%
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
T7552 H-1152 451462-58-1 98%
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
TQ0187 SR-3677 1072959-67-1 98%
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
T7391 SAR407899 923359-38-0 98%
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
T12746 ROCK inhibitor-2 1127308-52-4 98%
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
T1870 Y-27632 146986-50-7 98%
Y-27632 is a selective ATP-competitive inhibitor of ROCK-I and ROCK-II.
T4276 Hydroxyfasudil Hydrochloride 155558-32-0 98%
Hydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
T4095 ZINC00881524 557782-81-7 98%
ZINC00881524 is an effective and specific ROCK inhibitor.
T1911 Afuresertib 1047644-62-1 98%
Afuresertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
T1898 RKI-1447 1342278-01-6 98%
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
TQ0183 Narciclasine 29477-83-6 98%
Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
CID-5056270
T23888
CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma, ...
GKI-1 HCl
T11402L
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.
CRT0066854 hydrochloride
T10888
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 valu...
Ripasudil free base
T7492
Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
YAP/TAZ inhibitor-1
T13364
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
Y-9738
T13972
Y-9738 is an agent of hypolipidemic.
SB-772077B dihydrochloride
T16855
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
Cucurbitacin A
TN1533
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
Merestinib dihydrochloride
T15808
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
LX7101
T15798
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
H-1152
T7552
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
SR-3677
TQ0187
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
SAR407899
T7391
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
ROCK inhibitor-2
T12746
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
Y-27632
T1870
Y-27632 is a selective ATP-competitive inhibitor of ROCK-I and ROCK-II.
Hydroxyfasudil Hydrochloride
T4276
Hydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
ZINC00881524
T4095
ZINC00881524 is an effective and specific ROCK inhibitor.
Afuresertib
T1911
Afuresertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
RKI-1447
T1898
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
Narciclasine
TQ0183
Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
1 2 3