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ROCK

Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.
Cat No. product name
T7391 SAR407899 SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
T6321 Tofacitinib Tofacitinib is an oral, small molecule inhibitor of Janus kinases that is used to treat moderate-to-severe rheumatoid arthritis.
T4488 GSK-25 GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically impr...
T7885 Afuresertib hydrochloride Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
T7764 CCG-222740 CCG-222740 is an inhibitor of Rho/MRTF pathway
T1870 Y-27632 Y-27632 is a selective ATP-competitive inhibitor of ROCK-I and ROCK-II.
T3060 Fasudil hydrochloride Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
T6057 URMC-099 URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T23308 SAR407899 hydrochloride ATP-competitive ROCK inhibitor
T1606 Fasudil Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T13384L Y-33075 dihydrochloride Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
T1911 Afuresertib Afuresertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
T1725 Y-27632 dihydrochloride Y-27632 is a selective inhibitor of ROCKs including p160ROCK (Ki: 140 nM) and ROCK2 (IC50: 800 nM).
T19913 CKI-7 CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
T35328 H-1152 dihydrochloride H-1152 dihydrochloride (2HCl) 是一种膜渗透性和选择性的Rho-associated protein kinase (ROCK)的抑制剂。 H-1152 可抑制ROCK2、PKA、PKC、PKG、Aurora A和CaMK2的IC50值分别为 0.0120 μM、3.03 μM、5.68 μM...
T1898 RKI-1447 RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
T2155 Thiazovivin Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
T2011 RKI1313 RKI-1313 was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.
T2633 GSK429286A GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
T2482 AT13148 AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
TN1533 Cucurbitacin A Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
T7301 BDP5290 BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
T7552 H-1152 H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
T7492 Ripasudil free base Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
T12721 Rho-Kinase-IN-1 Rho-Kinase-IN-1 is a inhibitor of Rho kinase (ROCK) with Ki values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively
T12747 ROCK2-IN-2 ROCK2-IN-2 是 ROCK2 的特异性抑制剂(IC50 <1 μM)。
T12746 ROCK inhibitor-2 ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
T10358 Netarsudil Dihydrochloride Netarsudil hydrochloride is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP...
TQ0319 Ripasudil Ripasudil (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2).
TQ0110 ROCK-IN-2 Azaindole 1 is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
TQ0183 Narciclasine Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
TQ0187 SR-3677 SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
T6867 Belumosudil KD025 is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
T4095 ZINC00881524 ZINC00881524 is an effective and specific ROCK inhibitor.
T4276 Hydroxyfasudil Hydrochloride Hydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
T4276L Hydroxyfasudil Hydroxyfasudil is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
T3513 GSK180736A GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), b...
T3518 GSK269962A GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
T16855 SB-772077B dihydrochloride SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
T15808 Merestinib dihydrochloride Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
T15798 LX7101 LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
T14960 Chroman 1 Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM).
T14989 CMPD101 CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits ...
T13424 (1R,2S)-VU0155041 (1R,2S)-VU0155041 is a partial agonist of mGluR4(EC50 of 2.35 μM).
T13364 YAP/TAZ inhibitor-1 YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
T13972 Y-9738 Y-9738 is an agent of hypolipidemic.
SAR407899
T7391
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
Tofacitinib
T6321
Tofacitinib is an oral, small molecule inhibitor of Janus kinases that is used to treat moderate-to-severe rheumatoid arthritis.
GSK-25
T4488
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically impr...
Afuresertib hydrochloride
T7885
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
CCG-222740
T7764
CCG-222740 is an inhibitor of Rho/MRTF pathway
Y-27632
T1870
Y-27632 is a selective ATP-competitive inhibitor of ROCK-I and ROCK-II.
Fasudil hydrochloride
T3060
Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
URMC-099
T6057
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
SAR407899 hydrochloride
T23308
ATP-competitive ROCK inhibitor
Fasudil
T1606
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
Y-33075 dihydrochloride
T13384L
Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
Afuresertib
T1911
Afuresertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
Y-27632 dihydrochloride
T1725
Y-27632 is a selective inhibitor of ROCKs including p160ROCK (Ki: 140 nM) and ROCK2 (IC50: 800 nM).
CKI-7
T19913
CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
H-1152 dihydrochloride
T35328
H-1152 dihydrochloride (2HCl) 是一种膜渗透性和选择性的Rho-associated protein kinase (ROCK)的抑制剂。 H-1152 可抑制ROCK2、PKA、PKC、PKG、A...
RKI-1447
T1898
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
Thiazovivin
T2155
Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
RKI1313
T2011
RKI-1313 was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.
GSK429286A
T2633
GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
AT13148
T2482
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
Cucurbitacin A
TN1533
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
BDP5290
T7301
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
H-1152
T7552
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
Ripasudil free base
T7492
Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
Rho-Kinase-IN-1
T12721
Rho-Kinase-IN-1 is a inhibitor of Rho kinase (ROCK) with Ki values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively
ROCK2-IN-2
T12747
ROCK2-IN-2 是 ROCK2 的特异性抑制剂(IC50 <1 μM)。
ROCK inhibitor-2
T12746
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
Netarsudil Dihydrochloride
T10358
Netarsudil hydrochloride is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP...
Ripasudil
TQ0319
Ripasudil (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2).
ROCK-IN-2
TQ0110
Azaindole 1 is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
Narciclasine
TQ0183
Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
SR-3677
TQ0187
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
Belumosudil
T6867
KD025 is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
ZINC00881524
T4095
ZINC00881524 is an effective and specific ROCK inhibitor.
Hydroxyfasudil Hydrochloride
T4276
Hydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
Hydroxyfasudil
T4276L
Hydroxyfasudil is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
GSK180736A
T3513
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM),...
GSK269962A
T3518
GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
SB-772077B dihydrochloride
T16855
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
Merestinib dihydrochloride
T15808
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
LX7101
T15798
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
Chroman 1
T14960
Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM).
CMPD101
T14989
CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits ...
(1R,2S)-VU0155041
T13424
(1R,2S)-VU0155041 is a partial agonist of mGluR4(EC50 of 2.35 μM).
YAP/TAZ inhibitor-1
T13364
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
Y-9738
T13972
Y-9738 is an agent of hypolipidemic.