ROCK

Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.

Cat. No.	Product name	CAS No.	Purity
T7492	Ripasudil free base	223645-67-8	98%
Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
T23308	SAR407899 hydrochloride	923262-96-8	98%
ATP-competitive ROCK inhibitor
T13364	YAP/TAZ inhibitor-1	2093565-23-0	98%
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
T13972	Y-9738	59399-41-6	98%
Y-9738 is an agent of hypolipidemic.
T15808	Merestinib dihydrochloride	1206801-37-7	98%
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
TN1533	Cucurbitacin A	6040-19-3	98%
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
T16855	SB-772077B dihydrochloride	607373-46-6	98%
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
T7552	H-1152	451462-58-1	98%
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
T35328	H-1152 dihydrochloride	871543-07-6	98%

T1606	Fasudil	103745-39-7	98%
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T9652	SB-747651A Dihydrochloride	1781882-72-1	98%
SB-747651A Dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A Dihydrochloride also i...
T12747	ROCK2-IN-2	1995065-79-6	98%
ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
TQ0183	Narciclasine	29477-83-6	98%
Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
T7885	Afuresertib hydrochloride	1047645-82-8	100%
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
T19913	CKI-7	1177141-67-1	100.00%
CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
TQ0110	ROCK-IN-2	867017-68-3	97.59%
Azaindole 1 is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
T7301	BDP5290	1817698-21-7	98%
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
T2482	AT13148	1056901-62-2	98.04%
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T2633	GSK429286A	864082-47-3	98.42%
GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
T3513	GSK180736A	817194-38-0	98.44%
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), b...

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T7492

Ripasudil free base

223645-67-8

98%

Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.

T23308

SAR407899 hydrochloride

923262-96-8

98%

ATP-competitive ROCK inhibitor

T13364

YAP/TAZ inhibitor-1

2093565-23-0

98%

YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).

T13972

Y-9738

59399-41-6

98%

Y-9738 is an agent of hypolipidemic.

T15808

Merestinib dihydrochloride

1206801-37-7

98%

Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...

TN1533

Cucurbitacin A

6040-19-3

98%

Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...

T16855

SB-772077B dihydrochloride

607373-46-6

98%

SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).

T7552

H-1152

451462-58-1

98%

H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).

T35328

H-1152 dihydrochloride

871543-07-6

98%

T1606

Fasudil

103745-39-7

98%

Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.

T9652

SB-747651A Dihydrochloride

1781882-72-1

98%

SB-747651A Dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A Dihydrochloride also i...

T12747

ROCK2-IN-2

1995065-79-6

98%

ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).

TQ0183

Narciclasine

29477-83-6

98%

Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.

T7885

Afuresertib hydrochloride

1047645-82-8

100%

Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)

T19913

CKI-7

1177141-67-1

100.00%

CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).

TQ0110

ROCK-IN-2

867017-68-3

97.59%

Azaindole 1 is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.

T7301

BDP5290

1817698-21-7

98%

BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)

T2482

AT13148

1056901-62-2

98.04%

AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.

T2633

GSK429286A

864082-47-3

98.42%

GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).

T3513

GSK180736A

817194-38-0

98.44%

GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), b...