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ROCK

Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.
Cat. No. Product name CAS No. Purity Chemical Structure
T7492 Ripasudil free base 223645-67-8 98%
Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
T23308 SAR407899 hydrochloride 923262-96-8 98%
ATP-competitive ROCK inhibitor
T13364 YAP/TAZ inhibitor-1 2093565-23-0 98%
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
T13972 Y-9738 59399-41-6 98%
Y-9738 is an agent of hypolipidemic.
T15808 Merestinib dihydrochloride 1206801-37-7 98%
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
TN1533 Cucurbitacin A 6040-19-3 98%
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
T16855 SB-772077B dihydrochloride 607373-46-6 98%
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
T7552 H-1152 451462-58-1 98%
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
T35328 H-1152 dihydrochloride 871543-07-6 98%
T1606 Fasudil 103745-39-7 98%
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T9652 SB-747651A Dihydrochloride 1781882-72-1 98%
SB-747651A Dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A Dihydrochloride also i...
T12747 ROCK2-IN-2 1995065-79-6 98%
ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
TQ0183 Narciclasine 29477-83-6 98%
Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
T7885 Afuresertib hydrochloride 1047645-82-8 100%
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
T19913 CKI-7 1177141-67-1 100.00%
CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
TQ0110 ROCK-IN-2 867017-68-3 97.59%
Azaindole 1 is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
T7301 BDP5290 1817698-21-7 98%
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
T2482 AT13148 1056901-62-2 98.04%
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T2633 GSK429286A 864082-47-3 98.42%
GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
T3513 GSK180736A 817194-38-0 98.44%
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), b...
Ripasudil free base
T7492
Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
SAR407899 hydrochloride
T23308
ATP-competitive ROCK inhibitor
YAP/TAZ inhibitor-1
T13364
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
Y-9738
T13972
Y-9738 is an agent of hypolipidemic.
Merestinib dihydrochloride
T15808
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
Cucurbitacin A
TN1533
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
SB-772077B dihydrochloride
T16855
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
H-1152
T7552
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
H-1152 dihydrochloride
T35328
Fasudil
T1606
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
SB-747651A Dihydrochloride
T9652
SB-747651A Dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A Dihydrochloride also i...
ROCK2-IN-2
T12747
ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
Narciclasine
TQ0183
Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
Afuresertib hydrochloride
T7885
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
CKI-7
T19913
CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
ROCK-IN-2
TQ0110
Azaindole 1 is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
BDP5290
T7301
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
AT13148
T2482
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
GSK429286A
T2633
GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
GSK180736A
T3513
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), b...
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