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GSK269962A hydrochloride
🥰Excellent
Catalog No. T39519Cas No. 2095432-71-4
Alias GSK269962 hydrochloride, GSK 269962A hydrochloride, GSK 269962 hydrochloride
GSK269962A hydrochloride (GSK 269962 hydrochloride) is a potent and selective ROCK inhibitor with anti-inflammatory and vasodilatory effects, inhibits ROCK1 and ROCK2, and can be used in the study of acute myeloid leukemias.
GSK269962A hydrochloride
🥰Excellent
Catalog No. T39519Alias GSK269962 hydrochloride, GSK 269962A hydrochloride, GSK 269962 hydrochlorideCas No. 2095432-71-4
GSK269962A hydrochloride (GSK 269962 hydrochloride) is a potent and selective ROCK inhibitor with anti-inflammatory and vasodilatory effects, inhibits ROCK1 and ROCK2, and can be used in the study of acute myeloid leukemias.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $43 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GSK269962A hydrochloride (GSK 269962 hydrochloride) is a potent and selective ROCK inhibitor with anti-inflammatory and vasodilatory effects, inhibits ROCK1 and ROCK2, and can be used in the study of acute myeloid leukemias. |
| Targets&IC50 | ROCK1 (human):1.6 nM, vasodilatation in preconstricted rat aortas:35 nM |
| In vitro | GSK269962A hydrochloride is a potent ROCK inhibitor with IC50s of 1.6 nM and 4 nM for recombinant human ROCK1 and ROCK2, respectively. GSK269962A hydrochloride induced vasodilatation in preconstricted rat aortas with an IC50 of 35 nM.[1] |
| In vivo | GSK269962A hydrochloride (0.3, 1 and 3 mg/kg by gavage) induced a dose-dependent decrease in blood pressure in spontaneously hypertensive rats (SHR), with a rapid and significant antihypertensive effect. [1] |
| Alias | GSK269962 hydrochloride, GSK 269962A hydrochloride, GSK 269962 hydrochloride |
| Molecular Weight | 607.06 |
| Formula | C29H31ClN8O5 |
| Cas No. | 2095432-71-4 |
| Smiles | Cl.O=C(NC=1C=CC=C(OC2=NC=C3N=C(C4=NON=C4N)N(C3=C2)CC)C1)C5=CC=C(OCCN6CCOCC6)C=C5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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