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Belumosudil mesylate
🥰Excellent
Catalog No. T39555Cas No. 2109704-99-4
Alias SLx-2119 mesylate, SLx2119 mesylate, SAR445761, Rezurock Rezurock, KD025 mesylate, KD 025 mesylate
Belumosudil mesylate (KD025 mesylate) is a selective and highly efficient ROCK2 inhibitor with antifibrotic activity. It inhibits ROCK1 and can be used in chronic graft-versus-host disease research.
Belumosudil mesylate
🥰Excellent
Catalog No. T39555Alias SLx-2119 mesylate, SLx2119 mesylate, SAR445761, Rezurock Rezurock, KD025 mesylate, KD 025 mesylateCas No. 2109704-99-4
Belumosudil mesylate (KD025 mesylate) is a selective and highly efficient ROCK2 inhibitor with antifibrotic activity. It inhibits ROCK1 and can be used in chronic graft-versus-host disease research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $68 | In Stock | |
| 10 mg | $109 | In Stock | |
| 25 mg | $182 | In Stock | |
| 50 mg | $268 | In Stock | |
| 100 mg | $396 | In Stock | |
| 500 mg | $943 | In Stock |
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Belumosudil
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Product Introduction
Bioactivity
Chemical Properties
| Description | Belumosudil mesylate (KD025 mesylate) is a selective and highly efficient ROCK2 inhibitor with antifibrotic activity. It inhibits ROCK1 and can be used in chronic graft-versus-host disease research. |
| Targets&IC50 | ROCK2:105 nM (IC50), ROCK1:24 μM (IC50) |
| In vitro | Belumosudil mesylate is a selective inhibitor of ROCK2, with IC50s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively.[1] 40 μM Belumosudil mesylate significantly down-regulated the levels of Tsp-1 and CTGF mRNA in pulmonary artery smooth muscle cells (PASMC). [1] |
| In vivo | Intraperitoneal injection of 100, 200, or 300 mg/kg Belumosudil mesylate dose-dependently reduced infarct volume after transient middle cerebral artery occlusion. Belumosudil mesylate was at least as effective in aged, diabetic, or female mice as in normal adult male mice. [2] |
| Alias | SLx-2119 mesylate, SLx2119 mesylate, SAR445761, Rezurock Rezurock, KD025 mesylate, KD 025 mesylate |
| Molecular Weight | 548.61 |
| Formula | C27H28N6O5S |
| Cas No. | 2109704-99-4 |
| Smiles | O=C(NC(C)C)COC1=CC=CC(=C1)C=2N=C3C=CC=CC3=C(N2)NC=4C=CC=5NN=CC5C4.O=S(=O)(O)C |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 8.00 mg/mL (14.58 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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