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H-1152 dihydrochloride

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Purity:98.42%

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COA HNMR HPLC LCMS IC

H-1152 dihydrochloride

Catalog No. T35328Cas No. 871543-07-6

H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 values of 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.

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Pack Size	Price	Availability
1 mg	$58	In Stock
5 mg	$145	In Stock
10 mg	$239	In Stock
25 mg	$462	In Stock
50 mg	$728	In Stock
100 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$158	In Stock

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Product Introduction

Bioactivity

Description	H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 values of 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.
Targets&IC50	PKA (cell-free assay):3.03 μM, CaMK II (cell-free assay):0.180 μM, ROCK2 (cell-free assay):0.0120 μM, Aurora A (cell-free assay):0.745 μM, PKG (cell-free assay):0.360 μM
In vitro	H-1152 dihydrochloride shows less inhibitory activities against Src, MLCK, Abl, EGFR, MKK4, GSK3α, AMPK, and P38α, with IC50s of 3.06, 28.3, 7.77, 50.0, 16.9, 60.7, 100, and 100 μM, respectively[1]. H-1152 dihydrochloride slightly suppresses PKA, PKC and MLCK, with Kis of 0.63, 9.27, and 10.1 μM, respectively. In LPA-treated cells, H-1152 dihydrochloride (0.1-10 µM) inhibits MARCKS phosphorylation (IC50 = 2.5 µM)[2]. H-1152 dihydrochloride (0.5-10 μM) does not decrease neuronal survival or alter the ratios of different neuronal morphologies. H-1152 dihydrochloride (10 μM) arguments neurite length in both BMP4 and LIF cultures[3].
Alias	H-1152 2HCl, H-1152 dihydrochloride

Chemical Properties

Molecular Weight	392.34
Formula	C16H23Cl2N3O2S
Cas No.	871543-07-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 40 mg/mL (101.95 mM), Sonication is recommended.

H2O: 32.1 mg/mL (81.9 mM ), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5488 mL	12.7440 mL	25.4881 mL	127.4405 mL
5 mM	0.5098 mL	2.5488 mL	5.0976 mL	25.4881 mL
10 mM	0.2549 mL	1.2744 mL	2.5488 mL	12.7440 mL
20 mM	0.1274 mL	0.6372 mL	1.2744 mL	6.3720 mL
50 mM	0.0510 mL	0.2549 mL	0.5098 mL	2.5488 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0255 mL	0.1274 mL	0.2549 mL	1.2744 mL

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