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product7/Cevimeline-hydrochloride-hemihydrate.html

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  • Inhibitors & Agonists
    22
    TargetMol | Activity
  • Dye Reagents
    2
    TargetMol | inventory
Paroxetine hydrochloride hemihydrate
T1636L110429-35-1
Paroxetine hydrochloride hemihydrate (Paxil) is an effective and selective serotonin reuptake inhibitor (SSRI).
  • $30
In Stock
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TargetMol | Inhibitor Sale
UNC0064-12 hydrochloride (1430089-64-7(free base))
T2056L
UNC0064-12 hydrochloride is an inhibitor of VEGFR2.
  • $133
In Stock
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QTY
TargetMol | Inhibitor Sale
Betrixaban hydrochloride(330942-05-7(free base))
T4690
Betrixaban hydrochloride(330942-05-7(free base)) (PRT054021 hydrochloride) is a potent, selective, and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM).
  • $40
In Stock
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ML-7 hydrochloride
T3050110448-33-4
ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-muscle myosin light chain kinase, PKA, and PKC.
  • $30
In Stock
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TargetMol | Citations Cited
JMV 2959 hydrochloride (925238-89-7 free base)
T117192448414-54-6
JMV 2959 hydrochloride (925238-89-7 free base) is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells.
  • $35
In Stock
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TargetMol | Inhibitor Sale
rac-7-hydroxy Propranolol (hydrochloride)
T3623176275-67-7
rac-7-hydroxy Propranolol (hydrochloride) is a ring-hydroxylated isomer and metabolite of propranolol that is an antagonist at β-adrenergic receptors (0.95 potency relative to propranolol). It also demonstrates potent vasodilator activity (0.20 potency relative to propranolol; pA2 = 7.58).
  • $688
35 days
Size
QTY
Theophylline, 7-(2-(diethylamino)ethyl)-6-thio-, hydrochloride
T3483696313-22-3
Theophylline, 7-(2-(diethylamino)ethyl)-6-thio-, hydrochloride is a bioactive chemical.
  • Inquiry Price
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(+)-Cevimeline hydrochloride hemihydrate
T13460
(+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011), a potent muscarinic receptor agonist, shows promise as a therapeutic candidate for xerostomia in Sjogren's syndrome. It exhibits a broad pharmacological profile across various systems in animal models including mice, rats, guinea pigs, rabbits, and dogs. Metabolism studies using rat and dog liver microsomes reveal rapid absorption with peak plasma concentrations (Cmax) within one hour post-oral administration and a half-life (t1 2) between 0.4 to 1.1 hours. Bioavailability is 50% in rats and 30% in dogs. Metabolic analysis shows species-specific differences: rats produce S- and N-oxidized metabolites, while dogs produce only N-oxidized metabolites. Sex-based pharmacokinetic differences were noted in rats but not in dogs. In vitro studies indicate cytochrome P450 (CYP) and flavin-containing monooxygenase (FMO) involvement in the sulfoxidation and N-oxidation of SNI-2011, with CYP2D and CYP3A mainly responsible for sulfoxidation in rat liver microsomes.
  • $3,960
10-14 weeks
Size
QTY
A-7 hydrochloride
T2253879127-24-5
A-7 hydrochloride is a calmodulin antagonist and causes alterations in the subpopulation of CD44+CD24- in MDA-MB-231 cells.
  • $35
In Stock
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Cevimeline hydrochloride
T20131107220-28-0
Cevimeline HCl is an agonist of cholinergic that binds to muscarinic receptors. Muscarinic agonists in sufficient dosage can enhance the secretion of exocrine glands, such as salivary and sweat glands.
  • $59
5 days
Size
QTY
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride
T77873
Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride, is a topoisomerase I inhibitor that demonstrates effective antibody-drug conjugate (ADC) activity both in vivo and in vitro, with delivery to cells facilitated through targeted antibody conjugation [1].
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Theophylline, 7-(2-oxo-4-piperidinobutyl)-6-thio-, hydrochloride
T3483897769-20-5
Theophylline, 7-(2-oxo-4-piperidinobutyl)-6-thio-, hydrochloride is a bioactive chemical.
  • Inquiry Price
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(6R,7R)-4-Methoxybenzyl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride
T65519113479-65-5
(6R,7R)-4-Methoxybenzyl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65519 and the CAS number is 113479-65-5.
    7-10 days
    Inquiry
    trans-Cevimeline hydrochloride
    T29681107220-29-1
    AF 102A hydrochloride is a biochemical.
    • Inquiry Price
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    6-Methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochloride
    T644051006-21-9
    6-Methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T64405 and the CAS number is 1006-21-9.
      7-10 days
      Inquiry
      2-Amino-6-(propylamino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one hydrochloride
      T64682
      2-Amino-6-(propylamino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T64682.
        7-10 days
        Inquiry
        MFZ 10-7 hydrochloride
        T120251779796-36-9
        MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 (NAM).
        • $1,520
        1-2 weeks
        Size
        QTY
        Nafagrel hydrochloride hemihydrate
        T71178122956-67-6
        Nafagrel hydrochloride hemihydrate is a thromboxane A2 synthetase inhibitor.
        • $1,520
        6-8 weeks
        Size
        QTY
        (-)-Cevimeline hydrochloride hemihydrate
        T13421
        Cevimeline hydrochloride hemihydrate ((-)-SNI-2011), a novel muscarinic receptor agonist, is being explored as a potential treatment for xerostomia in Sjogren's syndrome, exhibiting an IC50 value indicative of its affinity for mAChR. This compound's pharmacological effects on the gastrointestinal, urinary, and reproductive systems, alongside its impact on various tissues, were thoroughly examined in species including mice, rats, guinea pigs, rabbits, and dogs. The metabolic breakdown of (-)-SNI-2011 was studied in vitro using rat and dog liver microsomes to assess its biotransformation. Upon oral administration, peak plasma concentrations were reached within an hour in both rats and dogs, showcasing rapid absorption and a subsequent decrease in concentration with a half-life ranging from 0.4 to 1.1 hours. Bioavailability was noted at 50% in rats and 30% in dogs. Metabolic pathways highlighted significant species differences, with both S- and N-oxidized metabolites identified in rats, but only N-oxidized metabolites in dogs. Additionally, gender differences in pharmacokinetics were observed in rats but were absent in dogs. In vitro studies pinpointed the involvement of cytochrome P450 (CYP) and flavin-containing monooxygenase (FMO) in the metabolism of (-)-SNI-2011, specifically through sulfoxidation and N-oxidation processes, respectively. CYP2D and CYP3A were identified as the primary enzymes responsible for sulfoxidation in rat liver microsomes.
        • $3,960
        10-14 weeks
        Size
        QTY
        HCV-IN-7 hydrochloride
        T11548L1449756-87-9
        HCV-IN-7 hydrochloride is an orally active and potent pan-genotypic HCV NS5A inhibitor [IC50s: 3-47 pM], exhibiting a superior pan-genotypic profile, a good pharmacokinetic profile, and favorable liver uptake.
        • $1,520
        Backorder
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        Cevimeline hydrochloride hemihydrate
        T2390153504-70-2
        Cevimeline hydrochloride hemihydrate is a novel muscarinic receptor agonist, used as a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
        • $36
        In Stock
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        W-7 hydrochloride
        T2079261714-27-0
        W-7 hydrochloride (W-7 HCl), a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has antitumor activity.
        • $30
        In Stock
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