info@targetmol.com    Tel: (857) 239-0968 / (617) 419-7131
Home > Tyrosine Kinase/Adaptors > VEGFR > Ponatinib
Ponatinib  
Catalog No. T2372    CAS 943319-70-8
Pack Size
Availability
Price/USD
Quantity
10mg
In Stock
38.00
100mg
In Stock
98.00
10mM * 1mL (in DMSO)
In Stock
48.00
50mg
In Stock
69.00
Bulk Size: Please Quote for Discount
Documents and Quality Management
Purity:99.00% COA Datasheet HNMR HPLC MSDS
Biological Activity:

Product Description:

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively.

Target:
Src; FGFR1; VEGFR2; PDGFRα; Abl;
Research Area:
Cardiovascular System
Chemical Information:
Molecular Weight 532.56
Formula C29H27F3N6O
CAS Number 943319-70-8
Solubility DMSO: 30 mg/mL (56.33 mM)
Storage 3 years -20°C powder;
2 years -80°C in solvent;
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.
Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Product Recommendations
  • SU6656, SU 6656 is a selective Src family kinase inhibitor with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM fo...
  • PP2, PP2, a Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM, ~100-fold less...
  • PP1, PP1 is a potent and selective Src inhibitor for Lck/Fyn with IC50 of 5 nM/ 6 nM.
  • Saracatinib , Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM, and potent to c-Yes, Fyn, Lyn, ...
  • PD173074, PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-2...

 

Reference

If you have additional questions, Please send us a message. * Required