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Mitochondria-Targeted Compound Library

Catalog No. L5300
  Library Compound List   Excel SDF

The mitochondrion is a double-membrane-bound discrete organelle found in most eukaryotic organisms, generating most of the cell's supply of adenosine triphosphate (ATP) and controlling the cellular basal metabolic rate, called as the cell's powerhouses. In addition to supplying cellular energy, mitochondria are the major source of ROS (reactive oxygen species) that reflect the level of cellular oxidative stress and play an important role in mitochondria ROS signaling such as apoptosis, proliferation, and aging, etc. In addition, the fine modulation of mitochondrial calcium (Ca2+) homeostasis plays a fundamental role in many of the processes involving this organelle. Mitochondrial Ca2+ accumulation is a tightly controlled process, in turn regulating functions as diverse as aerobic metabolism and induction of cell death. Mitochondrial DNA mutations may lead to many mitochondrial metabolic disorders, and are thought to contribute to aging by promoting apoptosis. Mitochondria therefore represent an attractive drug target for metabolic diseases, neurodegeneration, or hyperproliferative diseases (cancer). A number of pre-clinical and clinical data have shown that mitochondria as drug targets have great potential. Small molecule drugs or biologics can act on mitochondria through various pathways including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca2+ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.

Mitochondria-Targeted Compound Library from TargetMol, a unique collection of 447 compounds targeting mitochondria, can be used for research in mitochondrial medicine and related target study.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 447 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine;
  • Targets include mitochondria related targets, such as ATPase, mitochondria-associated hexokinase, Bcl-2, NADP, etc. and inhibitors for the autophagy initiating factor, ULK1, also include other promising mitochondria-targeted compounds such as lonidamine, paclitaxel, etc;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L5300)

Library Composition

ROS (35)
Dehydrogenase (26)
MAO (22)
Autophagy (22)
ATPase (20)
Mitochondrial Metabolism (18)
Antioxidant (16)
NF-κB (13)
COX (12)
Apoptosis (12)
BCL (11)
Endogenous Metabolite (9)
Estrogen/progestogen Receptor (7)
Microtubule Associated (7)
NADPH (7)
TNF (6)
HDAC (6)
PI3K (6)
Vitamin (6)
Akt (5)
ALK (5)
PDK (5)
DNA/RNA Synthesis (5)
Potassium Channel (5)
AMPK (5)
IL Receptor (5)
Adrenergic Receptor (5)
VEGFR (5)
IκB/IKK (4)
Reactive Oxygen Species (4)
P450 (4)
p53 (4)
GABA Receptor (4)
Caspase (4)
Mitophagy (4)
MMP (4)
Calcium Channel (4)
Topoisomerase (4)
NOS (4)
Antifungal (4)
HIF (3)
Glutaminase (3)
p38 MAPK (3)
OXPHOS (3)
PKC (3)
Histone Demethylase (3)
HIV Protease (3)
PDGFR (3)
RAAS (3)
Phospholipase (3)
HSP (3)
5-HT Receptor (3)
Sirtuin (3)
Carbonic Anhydrase (3)
Antibacterial (3)
Antibiotic (3)
Ferroptosis (3)
c-Met/HGFR (3)
Antiviral (3)
Epigenetic Reader Domain (3)
PPAR (2)
DNA Alkylation (2)
Cysteine Protease (2)
c-Kit (2)
Transferase (2)
CDK (2)
transporter (2)
mTOR (2)
Monoamine Oxidase (2)
Sodium Channel (2)
Tyrosinase (2)
Tyrosine Kinases (2)
NO Synthase (2)
PARP (2)
Antifection (2)
Opioid Receptor (2)
AhR (2)
Lipoxygenase (2)
Free radical scavengers (2)
LDL (2)
Dynamin (2)
Histamine Receptor (2)
Dopamine Receptor (2)
STAT (2)
Glutathione reductase (2)
ERK (2)
HIF/HIF Prolyl-Hydroxylase (2)
Glucocorticoid Receptor (2)
Integrin (2)
FLT (2)
AChR (2)
Thrombin (2)
JAK (2)
Parasite (1)
SGLT (1)
Serine Protease (1)
Somatostatin (1)
Sigma receptor (1)
Proteasome (1)
Src (1)
TRP/TRPV Channel (1)
ROR (1)
Trk receptor (1)
Syk (1)
Reverse Transcriptase (1)
TGF-beta/Smad (1)
PKA (1)
RAR/RXR (1)
Phosphatase (1)
Isocitrate Dehydrogenase (IDH) (1)
PAK (1)
CPT (1)
Gamma-secretase (1)
Fatty Acid Synthase (1)
FAAH (1)
Electron transport (1)
EGFR (1)
E1/E2/E3 Enzyme (1)
DUB (1)
Chloride channel (1)
Glucokinase (1)
CFTR (1)
CAT (1)
Casein Kinase (1)
CaMK (1)
ATM/ATR (1)
Aromatase (1)
Annexin A (1)
Aminopeptidase (1)
Gap Junction Protein (1)
GST (1)
Nrf2 (1)
MAPK (1)
NOD (1)
NMDAR (1)
MPO (1)
Monocarboxylate transporter (1)
Melatonin Receptor (1)
MEK (1)
Mdm2 (1)
lysosomal autophagy (1)
HBV (1)
LRRK2 (1)
Kinesin (1)
JNK (1)
IRAK (1)
Immunology & Inflammation related (1)
IAP (1)
HMG-CoA Reductase (1)
Hedgehog/Smoothened (1)
Wnt/beta-catenin (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE