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NF-κB Signaling Compound Library

Catalog No. L3800
  Library Compound List   Excel SDF

Nuclear factor-κB (NF-κB), a collective term for a family of transcription factors, includes five subunits: NF-κB1 (p50/p105), NF-κB2 (p52/p100), p65 (RelA), RelB, and c-Rel. The homodimers or heterodimers formed by two subunits bind to specific sequences known as the κB site on their target genes for DNA interaction and transcriptional activation. How NF-κB selectively recognizes a small subset of relevant κB sites from the large excess of potential binding sites is a critical step for stimulus-specific gene transcription (The fine-tuning of the NF-B DNA binding activity).While in an inactivated state, NF-κB is located in the cytosol complexed with the inhibitory protein IκBα. Through the intermediacy of integral membrane receptors, a variety of extracellular signals can activate the enzyme IκB kinase(IKK). IKK, in turn, phosphorylates the IκBα protein, which results in ubiquitination, dissociation of IκBα from NF-κB, and eventual degradation of IκBα by the proteasome. The activated NF-κB is then translocated into the nucleus where it binds to specific sequences of DNA called response elements (RE). The DNA/NF-κB complex then recruits other proteins such as coactivators and RNA polymerase, which transcribe downstream DNA into mRNA. A large array of genes involved in different processes of the immune and inflammatory responses, such as TNF-α, IL-1β, IL-6, and IL-8, chemokines, adhesion molecules, clone stimulating factors, is mediated by NF-κB. In TNF-α–induced apoptosis, TRAF1, TRAF2, XIAP, c-IAP1, and c-IAP2 were identified as gene targets of NF-kB transcriptional activity.

NF-κB Signaling Compound Library from TargetMol, a unique collection of 560 small molecules targeting NF-κB signaling, can be used for research in NF-κB signaling and high throughput screening and high content screening.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 560 compounds targeting NF-κB signaling for high throughput screening and high content screening;
  • Effective tool for research in NF-κB signaling and related drug screening;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L3800)

Library Composition

NF-κB (132)
HDAC (65)
IκB/IKK (35)
TNF (28)
COX (24)
PPAR (24)
NOD (17)
Autophagy (16)
Antioxidant (14)
P450 (13)
IL Receptor (12)
ROS (11)
ERK (11)
Apoptosis (11)
JNK (10)
Endogenous Metabolite (9)
Antiviral (8)
EGFR (8)
Nrf2 (7)
p38 MAPK (7)
STAT (7)
NOS (6)
Akt (6)
AChR (6)
Wnt/beta-catenin (6)
MMP (6)
IRAK (6)
CDK (5)
Estrogen/progestogen Receptor (5)
Lipoxygenase (5)
Sirtuin (5)
Vitamin (5)
PDE (5)
Caspase (4)
PI3K (4)
GABA Receptor (4)
Histamine Receptor (4)
Reactive Oxygen Species (4)
RIP kinase (4)
AMPK (4)
Tyrosinase (4)
Calcium Channel (4)
p53 (4)
HIV Protease (3)
Sodium Channel (3)
DNA/RNA Synthesis (3)
Mitochondrial Metabolism (3)
Beta Amyloid (3)
HIF (3)
Prostaglandin Receptor (3)
RAAS (3)
Reverse Transcriptase (3)
TGF-beta/Smad (3)
5-HT Receptor (3)
Phospholipase (3)
HSP (3)
VEGFR (3)
PKC (3)
Chloride channel (3)
TLR (3)
MAPK (2)
JAK (2)
TRP/TRPV Channel (2)
P-gp (2)
Mdm2 (2)
FAK (2)
MPO (2)
Retinoid Receptor (2)
GST (2)
MAO (2)
Src (2)
IAP (2)
Proteasome (2)
S6 Kinase (2)
Glucocorticoid Receptor (2)
Epigenetic Reader Domain (2)
Antifection (2)
PDK (2)
PKA (2)
Parasite (2)
ATPase (2)
CaMK (2)
Antibacterial (2)
Antibiotic (2)
Carbonic Anhydrase (1)
Keap1-Nrf (1)
Liver X Receptor (1)
Antifungal (1)
Reductase (1)
LRRK2 (1)
Opioid Receptor (1)
NPC1L1 (1)
LTR (1)
Potassium Channel (1)
S1P Receptor (1)
Aminopeptidase (1)
Serine Protease (1)
SGLT (1)
HIF/HIF Prolyl-Hydroxylase (1)
Somatostatin (1)
advanced glycation end products (1)
Immunology & Inflammation related (1)
Syk (1)
Adrenergic Receptor (1)
Adenosine Receptor (1)
IGF-1R (1)
Topoisomerase (1)
Transferase (1)
PARP (1)
PKM (1)
MALT (1)
HER (1)
NOD-like Receptor (NLR) (1)
Microtubule Associated (1)
NADPH (1)
Cannabinoid Receptor (1)
cell cycle arrest (1)
CFTR (1)
Chk (1)
cAMP (1)
c-Kit (1)
c-Myc (1)
Mitophagy (1)
Cysteine Protease (1)
Dehydrogenase (1)
DNA Alkylation (1)
DPP-4 (1)
HMG-CoA Reductase (1)
Bcr-Abl (1)
Casein Kinase (1)
Glucokinase (1)
Hedgehog/Smoothened (1)
ATM/ATR (1)
Haspin Kinase (1)
GSK-3 (1)
GPX (1)
Glutathione reductase (1)
Aurora Kinase (1)
MEK (1)
NADPH-oxidase (1)
Free radical scavengers (1)
FLT (1)
FGFR (1)
BACE (1)
BCL (1)
PERK (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE