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Key features: The mean Tanimoto value of the 50k Diversity Set PS8 is 0.898, with even lower values in the subsets (calculated with ECFP fingerprints) No compound overlap with the previous edition (PS8 does not overlap with P7) Lipinski Rule of Five and Veber criteria-compliant compounds were selected Reagents, reactive or unstable molecules were excluded PAINS filter families A, B, and C were applied Lilly MedChem Rules compliance is guaranteed