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TGF-beta/Smad Compound Library

Catalog No. L4100
  Library Compound List   Excel SDF

Members of the transforming growth factor-β (TGF-β) family control growth, differentiation and apoptosis of cells, and have important functions during embryonic development. There are three known isoforms of TGF-β (TGF-β1, TGF-β2 and TGF-β3) expressed in mammalian tissues. TGF-β isoforms signal through three surface receptors, known as the TGF-β type I, type II, and type III receptors (TβRI, TβRII, and TβRIII, respectively) which are expressed on the surface of many cell types such as fibroblasts, lymphocytes, and hemopoietic cells, etc. The binding of TGF-β and receptors transduces the signals by phosphorylating carboxy-terminal serine residues of receptor-regulated (R-) Smads. The activated R-Smads form hetero-oligomeric complexes with a common-partner (co-) Smad, that is, Smad4 in vertebrate cells. The complexes translocate into the nucleus where they regulate the expression of target genes.

TGF-beta/Smad Compound Library from TargetMol, a unique collection of 185 TGF-beta/Smad signaling targeted compounds, can be used for research in TGF-beta/Smad signaling and related drug screening (high throughput and high content screening).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Compound Libraries | TargetMol
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
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Product Description

  • A unique collection of 185 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
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Publications Cited TargetMol Libraries

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Library Composition

PKC (77)
TGF-beta/Smad (59)
ROCK (44)
Apoptosis (22)
ALK (19)
Autophagy (18)
PKA (16)
CDK (8)
ERK (8)
Antibacterial (7)
Akt (6)
Src (6)
Endogenous Metabolite (5)
S6 Kinase (5)
Serine/threonin kinase (5)
PDGFR (4)
Casein Kinase (4)
Calcium Channel (4)
CaMK (4)
VEGFR (4)
SGK (4)
Parasite (4)
DNA/RNA Synthesis (4)
BCL (3)
AMPK (3)
NF-κB (3)
Influenza Virus (3)
EGFR (3)
Antifungal (3)
p38 MAPK (3)
GSK-3 (2)
IGF-1R (2)
Antibiotic (2)
COX (2)
HIV Protease (2)
FGFR (2)
Sodium Channel (2)
Phosphatase (2)
MEK (2)
MAPK (2)
GRK (2)
Syk (2)
LDL (2)
FLT (2)
Tyrosine Kinases (2)
Wnt/beta-catenin (2)
Myosin (2)
5-HT Receptor (2)
Rho (2)
MLK (2)
p53 (1)
Ras (1)
Antiviral (1)
LRRK2 (1)
Trk receptor (1)
PAI-1 (1)
TAM Receptor (1)
STAT (1)
ATPase (1)
Reactive Oxygen Species (1)
mTOR (1)
Caspase (1)
Proton pump (1)
NOS (1)
YAP (1)
PI3K (1)
c-Met/HGFR (1)
RAAS (1)
JNK (1)
Virus Protease (1)
Estrogen Receptor/ERR (1)
PARP (1)
Serine Protease (1)
Nucleoside Antimetabolite/Analog (1)
Topoisomerase (1)
Aurora Kinase (1)
RIP kinase (1)
UGT (1)
Bcr-Abl (1)
AAK1 (AP2 associated kinase 1) (1)
BTK (1)
Antifection (1)
Opioid Receptor (1)
DNA Alkylation (1)
JAK (1)
HSV (1)
CCR (1)
Chk (1)
S1P Receptor (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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