Mini Fungal Metabolite Natural Product Screening Library

Mini Fungal Metabolite Natural Product Screening Library

Catalog No. L6001

For thousands of years，natural products produced by organisms in nature have been utilized as medicines. As early as the second century B.C., Artemisia caruifolia was used to treat malaria. In the early modern era, advances in microbiology, particularly Alexander Fleming's discovery of penicillin, have ushered in a new era of drug discovery from microorganisms. To this day, fungi remain an important source of drugs for infectious diseases. With the rapid development of genome sequencing technology and the exploration of biosynthetic gene clusters, more novel compounds from fungi have been discovered. Fungi can be isolated from soil, water, air, plants and other organisms. In particular, endophytic fungi produce secondary metabolites similar to those of their hosts. Fungal libraries with a high degree of biodiversity are important for both academic research and industry.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Special Note: Each screening well contains natural products from fungal strain metabolism, which are mixtures. For further study of the monomer, please inquire about service fees.

I. Advantages of Mini Fungal Metabolite Natural Product Screening Library

(1) Diversified Natural Product Structure: Fungi can produce a wide range of secondary metabolites with diverse structures. Each fungal screening plate (96-well) contains 80-88 strains, and each strain contains about 100 metabolized natural product structures, and our Mini Fungal Metabolite Natural Product Screening Library consists of 6 fungal screening plates, covering approximately 5,000-50,000 chemical structure spaces. This library is highly valuable for screening research and offers excellent cost-effectiveness.

(2) Large Number of Strains: currently, there are 11,400 collected samples and a total of 21,087 strains

Sample source	Number of samples	Number of strains
soil	4950	5034
plant	6450	16053
total	11400	21087

(3) Diverse Geographic Locations for Strain Collection: samples were collected from three major continents around the world, including 56 cities and regions such as Kenya, the United States, Canada, Myanmar, and China.

(4) Diversity of Collection Environments (Extreme Environments): We have also collected samples from different landscapes, including hills, mountains, plateaus, canyons, valleys, and bays.

(5) Biodiversity of the Fungal Library: currently, a total of 4,108 fungal species have been identified.

II. Key Features and Usage

(1) Design Principle: The Fungal Extracts Drug Screening Plate utilizes a high throughput screening technique, where extracts from a variety of strains after fermentation and extraction are placed in parallel on a plate in order to be screened for drug activity under uniform conditions. The fungal extracts are different in each well and contain about 500-1,000 natural small molecules.

(2) Drug Screening Method: The fungal extracts to be tested are separately added to the microwells of the screening plate, and then biological reagents containing target cells or enzymes are added to the wells. Next, the screening plate is incubated so that the fungal extracts interact with the target molecules. By detecting the bioactivity signals (e.g., fluorescence, absorbance, etc.) in each well or using other methods, it can be determined whether the extracts contain components with potential drug activity.

(3) Data Analysis: Screening results usually need to be processed and analyzed by bioinformatics methods to identify fungal extracts with drug activity. For the screened active extracts, further separation, purification and structural identification can be performed to determine the specific active ingredients.

(4) Application Fields: The method can be widely applied in various fields like new drug discovery of antimicrobial agents, antitumor agents, and antiviral agents.

III. The catalog price for the Mini Fungal Metabolite Natural Product Screening Library

Mini Fungal Metabolite Natural Product Screening Library

Volume	Concentration (10mg/mL)	Number of Strains	Catalog Price/Chinese Yuan
30 uL	10	528	26,400
50 uL	10	528	36,960
100 uL	10	528	73,920
200 uL	10	528	127,000

IV. Service Fee for monomer extraction

(1) Crude Extract Pricing

Specification	Catalog Price/ Chinese Yuan	Extractable monomer quantity	Remarks
1g	4,000	About 1mg	The quantity of the standard reference material
20g	30,000	About 2mg	The quantity for analysis or testing
100g	60,000	About 10mg	The finished product