Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Levamisole hydrochloride ((-)-Tetramisole hydrochloride) is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 g | In stock | $ 33.00 | |
10 g | In stock | $ 56.00 |
Description | Levamisole hydrochloride ((-)-Tetramisole hydrochloride) is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. |
In vitro | L-tetramisole (250 and 500 mg/mL) suppresses IFN synthesis in the cells from BALB/c and NZB mice. L-tetramisole (125 mg/mL) inhibits the IFN production only partially and this effect is observed when the IFN production is high. L-tetramisole affects the production of the physiological IFN, but not the production of IFN induced by Newcastle disease virus (NDV) in the peritoneal cells of mice or in L929 cells. [1] |
In vivo | Tetramisole leads to the mean faecal egg count rose from 3 weeks after treatment and remain continuously higher than those Closantel or Albendazole treated group up to 12 weeks after treatment. [2] Tetramisole reduces neuronal response amplitude in a dose-dependent manner in mouse cortex. Tetramisole also decreases axonal conduction velocity in mouse cortex. [3] Tetramisole significantly increases the stereotyped behavior (grooming, sniffing, biting and licking and head bobbing) of the mice when compared to the control group. Tetramisole significantly increases stereotyped behavior of the mice on days 3, 5 and 8 in comparison with respective control values. Tetramisole treatments (0.5 and 1 mg/kg) also significantly decreases the time needed to complete the negative geotaxis task and reduces landing foot splay. [4] |
Synonyms | (-)-Tetramisole hydrochloride |
Molecular Weight | 240.75 |
Formula | C11H12N2S·HCl |
CAS No. | 16595-80-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15.5 mg/mL (64.38 mM), Sonification and heating are recommended.
You can also refer to dose conversion for different animals. More
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Levamisole hydrochloride 16595-80-5 Metabolism Microbiology/Virology Neuroscience Phospholipase AChR Parasite HSV Inhibitor Levamisole Levamisole Hydrochloride (-)-Tetramisole hydrochloride inhibit Tetramisole Hydrochloride Herpes simplex virus inhibitor