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Apoptosis Compound Library

Catalog No. L9000
  Library Compound List   Excel SDF

Apoptosis is a form of programmed cell death that occurs in multicellular organisms. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's lifecycle. Apoptosis leads to characteristic cell changes (morphology): the cell breaks apart into multiple vesicles called apoptotic bodies, which undergo phagocytosis. Apoptosis is regulated by both pro-apoptotic (such as Fas receptor and caspases) and anti-apoptotic (such as Bcl-2 and IAP) factors. Disordered apoptosis is implicated in a variety of human diseases. Inhibition of apoptosis can result in a number of cancers, autoimmune diseases, inflammatory diseases, and viral infections. Excessive apoptosis may also be a feature of some conditions such as autoimmune diseases, neurodegenerative diseases, and ischemia-associated injury. Consequently, considerable interest has arisen in therapeutic strategies for cancer, autoimmune diseases, and neurodegenerative diseases by modulating apoptosis pharmacologically.

TargetMol’s collection of 1796 apoptosis-related compounds, Apoptosis Compound Library, is divided accordingly with compounds designed for either pro- or anti-apoptosis purposes and can be used for research in cancer and neurodegenerative diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 1796 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;
  • Targets include Bcl-2, Caspase, p53, TNF-alpha, and surviving, etc.;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L9000)

Library Composition

Apoptosis (1016)
Autophagy (369)
Endogenous Metabolite (114)
Ferroptosis (100)
NF-κB (93)
Antibacterial (89)
TNF (85)
EGFR (75)
Caspase (66)
BCL (59)
Reactive Oxygen Species (55)
JAK (54)
COX (50)
STAT (50)
DNA/RNA Synthesis (49)
p38 MAPK (48)
CDK (48)
ERK (48)
VEGFR (47)
Raf (46)
PI3K (44)
Antibiotic (42)
FLT (38)
Mitophagy (37)
HDAC (37)
HIV Protease (36)
Src (36)
PDGFR (34)
Antifungal (34)
Akt (34)
Parasite (34)
MEK (33)
p53 (32)
c-Kit (31)
c-RET (30)
Microtubule Associated (30)
mTOR (29)
Influenza Virus (28)
IL Receptor (28)
JNK (28)
FGFR (27)
Epigenetic Reader Domain (26)
Antioxidant (26)
E1/E2/E3 Enzyme (26)
Dehydrogenase (25)
Bcr-Abl (23)
HSP (22)
AMPK (22)
Aurora Kinase (22)
PARP (21)
Ras (21)
PKC (21)
PPAR (20)
Topoisomerase (20)
Nucleoside Antimetabolite/Analog (19)
Proteasome (19)
Interleukin (19)
RIP kinase (18)
Tyrosine Kinases (18)
Mdm2 (18)
HER (17)
AChR (16)
Virus Protease (16)
Mitochondrial Metabolism (16)
Histone Methyltransferase (16)
Phosphatase (16)
PERK (16)
MAPK (15)
Serine/threonin kinase (15)
Sirtuin (15)
c-Met/HGFR (14)
P450 (14)
IκB/IKK (14)
ROS (14)
NO Synthase (13)
GSK-3 (13)
DNA Alkylator/Crosslinker (13)
MMP (13)
Potassium Channel (12)
RAAS (12)
IAP (12)
HSV (12)
Lipoxygenase (12)
Calcium Channel (12)
Estrogen Receptor/ERR (11)
Estrogen/progestogen Receptor (11)
c-Myc (11)
ATPase (11)
Tyrosinase (11)
Wnt/beta-catenin (11)
PKA (11)
TRP/TRPV Channel (11)
IGF-1R (10)
PD-1/PD-L1 (10)
PDE (10)
DNA-PK (10)
Dopamine Receptor (10)
FAK (10)
Gamma-secretase (9)
Beta Amyloid (9)
Pim (9)
Chk (9)
DUB (9)
Histamine Receptor (9)
Sodium Channel (9)
Syk (9)
TAM Receptor (9)
Retinoid Receptor (9)
Phospholipase (8)
Nrf2 (8)
SARS-CoV (8)
AChE (8)
TGF-beta/Smad (8)
PLK (8)
Trk receptor (8)
TLR (8)
5-HT Receptor (8)
Drug Metabolite (8)
c-Fms (8)
Fatty Acid Synthase (8)
DNA Alkylation (7)
NADPH (7)
Reverse Transcriptase (7)
Casein Kinase (7)
Adrenergic Receptor (7)
HIF/HIF Prolyl-Hydroxylase (7)
HBV (7)
GPR (7)
PDK (7)
HMG-CoA Reductase (7)
HIF (7)
HCV Protease (7)
P-gp (7)
Histone Acetyltransferase (6)
S6 Kinase (6)
Antifolate (6)
BTK (6)
Kinesin (6)
CaMK (6)
Cysteine Protease (6)
ALK (6)
Prostaglandin Receptor (6)
NOS (5)
GluR (5)
Glutathione Peroxidase (5)
MAO (5)
UGT (5)
Monoamine Oxidase (5)
ROCK (5)
S1P Receptor (5)
Anti-infection (5)
Rho (5)
Opioid Receptor (5)
Integrin (5)
DHFR (4)
Serine Protease (4)
ASK (4)
Aryl Hydrocarbon Receptor (4)
PTEN (4)
ROR (4)
ATM/ATR (4)
DPP-4 (4)
DNA Methyltransferase (4)
OXPHOS (4)
PAK (4)
MRP (4)
CSF-1R (4)
iGluR (4)
Antiviral (4)
Histone Demethylase (4)
MLK (4)
Telomerase (4)
GABA Receptor (4)
Transferase (4)
Proton pump (3)
IRE1 (3)
TOPK (3)
PAI-1 (3)
CRISPR/Cas9 (3)
Adenosine Receptor (3)
Pyroptosis (3)
IFNAR (3)
DNA (3)
Acyltransferase (3)
PGE Synthase (3)
Hexokinase (3)
GPX (3)
MNK (3)
Leukotriene Receptor (3)
STING (3)
FXR (3)
NADPH-oxidase (3)
NAMPT (3)
Glucocorticoid Receptor (3)
Glucokinase (3)
NOD-like Receptor (NLR) (3)
LTR (3)
Survivin (3)
Lipid (3)
Reductase (3)
Progesterone Receptor (2)
Antifection (2)
BACE (2)
BMI-1 (2)
Aromatase (2)
VDA (2)
VDAC (2)
cAMP (2)
Aminopeptidase (2)
Xanthine Oxidase (2)
Smo (2)
SGK (2)
Androgen Receptor (2)
YAP (2)
CRM1 (2)
Immunology/Inflammation related (2)
LRRK2 (2)
LPL Receptor (2)
Myosin (2)
Liver X Receptor (2)
FLAP (2)
NOD (2)
IRAK (2)
P2 Receptor (2)
P2X Receptor (2)
Free radical scavengers (2)
PAFR (2)
Hck (2)
Hedgehog/Smoothened (2)
PAD (2)
KSP (1)
Arginase (1)
lysosomal autophagy (1)
Stearoyl-CoA Desaturase (SCD) (1)
ACK (1)
Wee1 (1)
Hydrogenase (1)
Glutathione reductase (1)
Lipase (1)
Adenosine deaminase (1)
Guanylate cyclase (1)
Thrombin (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
Tie-2 (1)
KLF (1)
GNRH Receptor (1)
Amino Acids and Derivatives (1)
Somatostatin (1)
transporter (1)
GTPase (1)
IDO (1)
AhR (1)
GST (1)
Sigma receptor (1)
Melatonin Receptor (1)
OCT (1)
cholecystokinin (1)
PKM (1)
Chloride channel (1)
CFTR (1)
CXCR (1)
p97 (1)
Dynamin (1)
Endothelin Receptor (1)
PYK2 (1)
Ephrin Receptor (1)
Carbonic Anhydrase (1)
RAR/RXR  (1)
Epoxide Hydrolase (1)
FAAH (1)
MTH1 (1)
Fas/FasL (1)
NPC1L1 (1)
Beta-Secretase (1)
Norepinephrine (1)
NMDAR (1)
RSV (1)
Neurokinin receptor (1)
Neprilysin (1)
Na+/Ca2+ Exchanger (1)
FOXO1 (1)
SGLT (1)
PI4K (1)
SIK (1)
Hippo pathway (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE